http://localhost:80/xmlui/handle/123456789/12745 2026-04-23T14:14:26Z 2026-04-23T14:14:26Z Yahya, Ahmad Nuri, MMH http://localhost:80/xmlui/handle/123456789/13903 2022-10-28T10:23:25Z 2019-09-23T00:00:00Z

Title: Contemporary biological therapies for cardiovascular diseases Authors: Yahya, Ahmad; Nuri, MMH Abstract: Cardiovascular diseases are top cause of mortality in the world. Current interventional therapy and pharmacotherapy may alleviate symptoms or slow disease progression but are unable to cure or treat them. Molecular and pathophysiological advances have paved the way for contemporary biological therapies to be tested and standardized for the treatment of these diseases. Stem cells therapy and gene therapy has shown promise in the treatment of CVDs. Various types of stem cells used in cardiac conditions like myocardial infarction with the aim of regenerating the damaged myocardium have had variable success rates in clinical and preclinical trials. Improvements in methods and routes of cell delivery have improved clinical outcomes. Gene therapy employs therapeutic genes to treat diseases. Advances in vectors have improved transfection efficiencies and transgene expression and enhanced role in Heart failure, ischemic disease as well as arrhythmias. Clinical trials have shown improved cardiac function upon treatment with genes which promote angiogenesis. The current review looks at the role of these biological therapies in cardiovascular diseases.

2019-09-23T00:00:00Z Khuda, Fazli Ovais, Muhammad Zakiullah Khan, Ayub Ali, Gowhar Ullah, Sami Ali Shah, Waheed Abdul Qadar, Nizamuddin http://localhost:80/xmlui/handle/123456789/13902 2022-10-28T10:21:57Z 2019-09-22T00:00:00Z

Title: Drug-food interactions of commonly available juices of Pakistan Authors: Khuda, Fazli; Ovais, Muhammad; Zakiullah; Khan, Ayub; Ali, Gowhar; Ullah, Sami; Ali Shah, Waheed; Abdul Qadar, Nizamuddin Abstract: Medicines are often consumed concurrently with food; sometimes to improve its absorption and efficacy. However, certain foods may modify the function of drug metabolizing enzymes or transport mechanisms that are crucial determinants of systemic drug availability. Extensive work has been reported on certain juices like grapefruit that affects the bioavailability of more than 60 medications. However, relatively less work has been reported on certain other commonly used fruit juices, especially in Pakistan, such as mango, strawberry, apple, banana, pomegranate and grape etc. Present review has taken an account of the current work done in this area.

2019-09-22T00:00:00Z Kiang Lim, Chan Ying Gan1, Shu Yi, Vivien Jong, Mian Onn Leong, Chee Wai Mai, Chun Fei Chee, Chin http://localhost:80/xmlui/handle/123456789/13901 2022-10-28T10:16:37Z 2019-09-21T00:00:00Z

Title: Cytotoxic activity of phytochemicals from the stem bark of Calophyllum castaneum Authors: Kiang Lim, Chan; Ying Gan1, Shu; Yi, Vivien; Jong, Mian; Onn Leong, Chee; Wai Mai, Chun; Fei Chee, Chin Abstract: Phytochemical investigation on the dichloromethane stem bark extract of Calophyllum castaneum resulted in the isolation of five compounds, namely isoblancoic acid (1), blancoic acid (2), euxanthone (3), friedelin (4) and friedelinol (5). All these compounds were isolated for the first time from this plant. Their chemical structures were elucidated based on the spectroscopic analyses. The cytotoxicity of compounds 1-5 was assessed on a panel of cancer cell lines including bone (Saos-2, mg63), colorectal (HT29, Caco-2, HCC2998, SW48, HCT116, KM12), liver (HepG2), lung (H1299, Calu-3), and brain (C6), using 5-fluorouracil as positive control. Pronounced antiproliferative activities were observed for compound 1 which exhibited a comparable activity with the positive control, against brain (C6) and colorectal (SW48, KM12, HCT116) cancer cell lines showing IC50 values in the range of 14 to 65µM. Meanwhile, compound 5 displayed a greater cytotoxic effect showing at least 2-fold more strongly than the positive control, against C6 brain cancer cells. The assay findings have unveiled the therapeutic value of phytochemicals from Calophyllum castaneum as anti-cancer agents

2019-09-21T00:00:00Z Ali, Ijaz H Rizwani, Ghazala Rasheed, Munawwer Ali, Mohsin Hassan, Amir Hassan, Sohail Ishrat, Ghazala Zaheer Hussain, Kanwal Rehman, Sana http://localhost:80/xmlui/handle/123456789/13900 2022-10-28T10:16:14Z 2019-09-20T00:00:00Z

Title: Chemical analysis of Dalbergia sissoo (Roxb.) pod oil by (GC-MS) / GC-FID and evaluation of antioxidant potential Authors: Ali, Ijaz; H Rizwani, Ghazala; Rasheed, Munawwer; Ali, Mohsin; Hassan, Amir; Hassan, Sohail; Ishrat, Ghazala; Zaheer; Hussain, Kanwal; Rehman, Sana Abstract: Dalbergia sissoo (Roxb.) is one of the important plant species having extensive commercial and medicinal uses. The current study aims to assess the chemical constituents in pod oil of Dalbergia sissoo (Roxb.) by using two spectroscopic techniques i.e. GC-FID (Gas Chromatography Flame Ionization Detection) and GC-MS (Gas Chromatography Mass Spectroscopy). In GC-FID technique, nine fatty acids were identified with their respective composition, capric acid (1) (1.496%) lauric acid (2) (5.695%), myristic acid (3) (4.925%), palmitic acid (4) (10.130%), palmitoleic acid (5) (2.166%), stearic acid (6) (2.862%), oleic acid (7) (10.232%), linoleic acid (8) (22.350%) and behenic acid (9) (9.283%). In second technique, i.e. GC-MS, a series of hydrocarbons (10-37) along with two triterpenoids (38-39) were found in pod oil of the plant used. Important structure indices such as Iodine value and Saponification values were also determined. These findings can be helpful to understand the important medicinal and commercial aspects of seeds oil of the plant, like fuel value, degree of unsaturation and oxidative stability. Antioxidant testing (DPPH-Radical Scavenging Assay) was also performed on pods oil but no any significant activity was found.

2019-09-20T00:00:00Z