http://localhost:80/xmlui/handle/123456789/14253 2026-04-22T22:34:11Z 2026-04-22T22:34:11Z Khan, Abdul Arif Khurshid, Mohsin Tawfik, AF http://localhost:80/xmlui/handle/123456789/15110 2022-12-15T04:37:51Z 2013-09-28T00:00:00Z

Title: In vitro evaluation of vincristine and fluconazole combination against Candida Authors: Khan, Abdul Arif; Khurshid, Mohsin; Tawfik, AF Abstract: Infections associated with cancer are a major scourge and cause of substantial morbidity and mortality in cancer patients. The aim of present study was to appraise the in vitro activity of anticancer agent vincristine and antifungal fluconazole alone and in combination against Candida spp. Results were interpreted in terms of fractional inhibitory concentration index (FICI). Antifungal activity of fluconazole showed marked synergism when used in combination with vincristine, with FICI ranging from 0.25-0.5 against different Candida spp. Although, the use of vincristine with fluconazole is always disputed due to its side effects including decreased peristalsis, but the present research can help to perform suitability analysis of fluconazole use in life threatening invasive candidiasis associated with cancer patients. In addition, the synergism in antifungal activity after using with vincristine also warrants further research in the direction of minimizing adverse reaction associated with combined use of fluconazole and vincristine.

2013-09-28T00:00:00Z Mirza, Asaad Javaid Ahmad, Taqi Mohammad Mohammad, Taqi Khan, Zahid Akhter http://localhost:80/xmlui/handle/123456789/15108 2022-12-15T04:35:38Z 2013-09-27T00:00:00Z

Title: Evaluation of various concentrations of alkaline surface treatment on interfacial bond strengths of amalgam bonded to amalgam Authors: Mirza, Asaad Javaid; Ahmad, Taqi Mohammad; Mohammad, Taqi; Khan, Zahid Akhter Abstract: This study was done to assess the influence of alkaline surface modification on interfacial bond strength of existing fractured (old) amalgam restoration bonded to fresh amalgam. Old and Fresh amalgam interfaced samples were prepared by applying a 4-methacryloyloxyethy trimellitate anhydride (4-META) containing adhesive. The adhesive used was Amalgabond (Parkell, Farmingdale, NY 11735, USA). Four concentrations of calcium hydroxide Ca(OH)2 solutions were used as a surface modifiers for old amalgam to increase the pH of the amalgam surfaces. The concentrations used were 2.5, 5, 10 and 15%. Direct measurement of the interfacial bond strength was carried out using an electromechanical universal tensile testing machine at crosshead speed of 10mm per minute. Results show that all the calcium hydroxide modified samples produced the increased tensile bond strength (TBS) as compared to their control group. The highest values of bond strength were achieved using 15% Ca(OH)2 solution as surface modifier. Pretreatment of fractured amalgam with calcium hydroxide improves the bond strength of 4-META adhesives. Its use in repair of amalgam may therefore be considered.

2013-09-27T00:00:00Z Mohamed, Norazlina Yin, Chai Mei Shuid, Ahmad Nazrun Muhammad, Norliza Babji, Abdul Salam Soelaiman, Ima Nirwana http://localhost:80/xmlui/handle/123456789/15106 2022-12-15T04:27:02Z 2013-09-26T00:00:00Z

Title: The effects of Cosmos caudatus (Ulam Raja) supplementation on bone biochemical parameters in ovariectomized rats Authors: Mohamed, Norazlina; Yin, Chai Mei; Shuid, Ahmad Nazrun; Muhammad, Norliza; Babji, Abdul Salam; Soelaiman, Ima Nirwana Abstract: Cosmos caudatus (ulam raja) contains high mineral content and possesses high antioxidant activity which may be beneficial in bone disorder such as postmenopausal osteoporosis. The effects of C. caudatus on bone metabolism biomarkers in ovariectomized rats were studied. 48 Sprague-Dawley rats aged three months were divided into 6 groups. One group of rats was sham-operated while the remaining rats were ovariectomized. The ovariectomized rats were further divided into 5 groups: the control, three groups force-fed with C. caudatus at the doses of 100mg/kg, 200mg/kg or 300mg/kg and another group supplemented with calcium 1% ad libitum. Treatments were given 6 days per week for a period of eight weeks. Blood samples were collected twice; before and after treatment. Parameters measured were bone resorbing cytokine; interleukin-1 and the bone biomarkers; osteocalcin and pyridinoline. Serum IL-1 and pyridinoline levels were significantly increased in ovariectomized rats. Supplementation of C. caudatus was able to prevent the increase of IL-1 and pyridinoline in ovariectomized rats. Besides that, C. caudatus showed the same effect as calcium 1% on biochemical parameters of bone metabolism in ovariectomized rats. In conclusion, Cosmos caudatus was as effective as calcium in preventing the increase in bone resorption in ovariectomized rats

2013-09-26T00:00:00Z Zhou, Cunliu Li, Jun Tan, Shengjiang Ye, Huiqiong http://localhost:80/xmlui/handle/123456789/15103 2022-12-15T04:22:49Z 2013-09-25T00:00:00Z

Title: Selective extraction of berberine and palmatine from Huangbai powder Authors: Zhou, Cunliu; Li, Jun; Tan, Shengjiang; Ye, Huiqiong Abstract: Berberine and palmatine are two of the main bioactive components in Huangbai, a major Chinese medicinal herb. The current methods to extract these compounds usually involving the usage of inorganic acid and base, are not only complex and time-consuming, but have a low selectivity. In this paper, it was reported that hexane, ethyl acetate and dichloromethane were tested to extract berberine and palmatine from Huangbai powder. The results showed that dichloromethane extracted selectively and effectively berberine and palmatine from Huangbai powder among the examined solvents. In addition, dichloromethane can be recycled and reused, making it a potential candidate for large scale extraction of berberine and palmatine from Huangbai.

2013-09-25T00:00:00Z