http://localhost:80/xmlui/handle/123456789/14255 2026-04-23T14:14:27Z 2026-04-23T14:14:27Z Abdulazeez, Sheriff Sheik Ponnusamy, Ponmurugan http://localhost:80/xmlui/handle/123456789/15218 2022-12-15T10:21:57Z 2016-01-20T00:00:00Z

Title: Antioxidant and hypoglycemic activity of strawberry fruit extracts against alloxan induced diabetes in rats Authors: Abdulazeez, Sheriff Sheik; Ponnusamy, Ponmurugan Abstract: The strawberries (Fragaria x ananassa) of Rosaceae family are an accomplished source of bioactive compounds such as ascorbic acid and diverse range of polyphenols including anthocyanins, phenolic acids, flavonols, ellagitannins etc. These phenolic compounds classify strawberry as an important health promoting food. Strawberries are proved to have potent antioxidant capacity in various in vitro assay systems. The in vivo beneficial effects are getting explored against various ailments including cancer, metabolic syndrome, and cardiovascular diseases. The present research study was designed to analyze the effect of strawberry fruit extracts (water and methanol) against alloxan induced hyperglycemia in albino rats of Wister strain. Upon alloxan (150mg/kg body weight) induction, the diabetic animals showed marked increase in the values of plasma glucose, urea, uric acid, creatinine and concomitant decrease in body weight and plasma insulin level. The oral administration of strawberry extracts for 45 days in diabetic animals reversed the biochemical changes significantly (P0.05) to near normal. Furthermore, the restoration of body weight loss was also observed. The results suggest that the strawberry extract has effective hypoglycemic activity against alloxan diabetes. The poly phenolic antioxidant contents of the strawberry fruit extracts are responsible for the observed biological effect.

2016-01-20T00:00:00Z Bushra, Rabia Sial, Ali Akbar Rizvi, Mehwish Shafiq, Yousra Aslam, Nousheen Bano, Nusrat http://localhost:80/xmlui/handle/123456789/15217 2022-12-15T10:21:32Z 2016-01-20T00:00:00Z

Title: Sensitivity pattern of ceftriaxone against different clinical isolates Authors: Bushra, Rabia; Sial, Ali Akbar; Rizvi, Mehwish; Shafiq, Yousra; Aslam, Nousheen; Bano, Nusrat Abstract: Emerging resistance against broad-spectrum antibiotics for standard empiric therapy is a global concern. Ceftriaxone (broad spectrum, third generation cephalosporin) is widely used in tertiary care settings to treat severe bacterial infections usually non-responsive to other antibiotics. The aim of the study is to evaluate the current sensitivity pattern of ceftriaxone (30µg/disk) among different clinical isolates. For this purpose, three hundred clinical isolates including Escherichia coli (25%), Staphylococcus aureus (30%), Salmonella typhi (17%) and Klebsiella pneumoniae (20%) were collected from different pathological laboratories of Karachi, Pakistan. The in-vitro sensitivity of different Gram positive and Gram-negative bacteria was determined by disk-diffusion technique using 0.5 McFarland standard. Results showed that ceftriaxone was highly sensitive against Escherichia coli (90%) and least sensitive against Klebsiella pneumoniae (65%). It is concluded that the sensitivity of ceftriaxone is progressively decreasing in comparison with past studies creating an alarming situation. Therefore, continuous surveillance is required to determine the current resistance status of clinical pathogens and for effective anti-microbial therapy.

2016-01-20T00:00:00Z Qadir, Muhammad Imran http://localhost:80/xmlui/handle/123456789/15216 2022-12-15T10:21:07Z 2016-01-20T00:00:00Z

Title: Qadir test Authors: Qadir, Muhammad Imran Abstract: The present diagnostic tests for cancers are expensive and are not accessible by poor. Therefore, it was necessary to explore a diagnostic test accessible by general public. Plasma lipid profile is decreased in all the cancers except in breast cancer, where HDL-cholesterol is decreased while the other lipids are increased. Therefore, plasma lipid profile may be used as diagnostic test for malignancy. As general diagnostic procedures, these laboratory parameters (plasma lipids) should also be co-related with the clinical symptoms of the patient and other diagnostic tools.

2016-01-20T00:00:00Z Zahari, Zalina Siong, Lee Chee Musa, Nurfadhlina Azhar, Muhammad Yasin, Muhammad Ismail, Rusli http://localhost:80/xmlui/handle/123456789/15215 2022-12-15T10:20:34Z 2016-01-20T00:00:00Z

Title: Demographic profiles and sleep quality among patients on methadone maintenance therapy (MMT) in Malaysia Authors: Zahari, Zalina; Siong, Lee Chee; Musa, Nurfadhlina; Azhar, Muhammad; Yasin, Muhammad; Ismail, Rusli Abstract: Poor sleep quality was frequently reported by opioid dependence patients during methadone maintenance therapy (MMT). The study investigated a sample of patients on MMT to investigate the severity and prevalence of sleep problems in MMT patients. We evaluated sleep quality and disturbances of 119 Malay male patients from MMT clinics in Kelantan, Malaysia between March and July 2013 using the Pittsburgh Sleep Quality Index (PSQI)-Malay version. Patients’ demographic, clinical data, past drug history and methadone treatment variables were recorded. Patients averaged 37.5 years of age (SD 6.79) and their mean age of first time illicit drug use was 19.3 years (SD 4.48). Their mean age of entering MMT was 34.7 years (SD 6.92) and the mean duration in MMT was 2.8 years (SD 2.13). The mean current daily dosage of methadone was 77.8 mg (SD 39.47) and ranged from 20 to 360 mg. The mean global PSQI score was 5.6 (SD 2.79) and 43.7% patients were identified as ‘poor sleepers’ (global PSQI scores >5). This study confirms the poor overall sleep quality among patients on MMT. The prevalence and severity of sleep problems in MMT patients should not be underestimated.

2016-01-20T00:00:00Z