http://localhost:80/xmlui/handle/123456789/14319 2026-04-23T04:59:24Z 2026-04-23T04:59:24Z Wong, Ang Peng Kassab, Yaman Walid Mohamed, Abdul Latiff Abdul Qader, Amelah Mohammed http://localhost:80/xmlui/handle/123456789/15298 2022-12-19T10:35:26Z 2018-01-20T00:00:00Z

Title: Beyond conventional therapies: Complementary and alternative medicine in the management of hypertension: An evidence-based review Authors: Wong, Ang Peng; Kassab, Yaman Walid; Mohamed, Abdul Latiff; Abdul Qader, Amelah Mohammed Abstract: Hypertension is one of the major causes of morbidity and mortality. Worldwide, Hypertension is estimated to cause 7.5 million deaths, about 12.8% of the total of all deaths. This accounts for 57 million disability adjusted life years (DALYS) or 3.7% of total DALYS. This led WHO to set a target of 25% reduction in prevalence by 2025. To reach that, WHO has adopted non-conventional methods for the management of hypertension? Despite worldwide popularity of such non-conventional therapies, only small volume of evidence exists that supports its effectiveness. This review attempted to make a critical appraisal of the evidence, with the aim to (1) describe the therapeutic modalities frequently used, and (2) review the current level of evidence attributable to each modality. Databases from Cochrane Library, MEDLINE, PUBMED, and EMBASE were searched from 2005-2015. A total of 23 publications have been identified and selected. Out of these, 15 systematic reviews and/or meta-analysis of RCTs, 5 RCTs, 1 non-RCT, and 2 observational studies without control. Among those 23 publications, therapeutic modalities identified are: fish oil, qigong, yoga, coenzyme Q10, melatonin, meditation, vitamin D, vitamin C, monounsaturated fatty acids, dietary aminoacids, chiropractic, osteopathy, folate, inorganic nitrate, beetroot juice, beetroot bread, magnesium, and L-arginine. The followings were found to have weak or no evidence: fish oil, yoga, vitamin D, monounsaturated fatty acid, dietary amino-acids, and osteopathy. Those found to have significant reduction in blood pressure are: magnesium, qigong, melatonin, meditation, vitamin C, chiropractic, folate, inorganic nitrate, beetroot juice and L-arginine. Coenzyme Q10on the other hand, showed contradicting results were some studies found weak or no effect on blood pressure while others showed significant blood pressure reduction effect. By virtue of the research designs and methodologies, the evidence contributed from these studies is at level 1. Results from this review suggest that certain non-conventional therapies may be effective in treating hypertension and improving cardiac function and therefore considered as part of an evidencebased approach.

2018-01-20T00:00:00Z Beril Anılanmert Ibrahim Narın Ibrahim Aydın Munevver Acıkkol http://localhost:80/xmlui/handle/123456789/15294 2022-12-19T10:30:42Z 2018-01-20T00:00:00Z

Title: Fast chromatographic screening method for 7 drugs of potential threat in drug facilitated crimes Authors: Beril Anılanmert; Ibrahim Narın; Ibrahim Aydın; Munevver Acıkkol Abstract: In cases where pharmaceuticals and pharmaceutical candidates are involved in drug facilitated crimes (DFC), like organ theft, robbery, rape and suicides, the analysis of drug powders or solution residues found in crime scenes may give idea on what the victims have ingested. An easy and fast simultaneous determination of 7 drugs; GHB (γhydroxybutyrate), GBL (γ-butyrolactone), norketamine, ketamine, fenobarbital, fenitoin and thiopental which have the potential to be used in DFC was performed. The method required no sample preparation and has 12 minutes elution time with a good chromatographic separation. The separation was carried out on a C18 monolithic column with UV detection at 215 and 237nm. All r2 values were ≥0.99 and the linear ranges were between 0.9956-1.0000. The LOD and LOQ values were between 0.56-5.55µgmL-1 and 1.69-16.82µgmL-1 respectively. The repeatability values were ≤7.35%. This is the first study in the simultaneous screening of the above mentioned drugs using HPLC

2018-01-20T00:00:00Z Bing Wang Ling Ma Lei Yin Jing Chen Yuanbin Zhang Lin Dong Xinhui Zhang Xueyan Fu http://localhost:80/xmlui/handle/123456789/15292 2022-12-19T10:29:06Z 2018-01-20T00:00:00Z

Title: Regional variation in the chemical composition and antioxidant activity of Rosmarinus officinalis L. from China and the Mediterranean region Authors: Bing Wang; Ling Ma; Lei Yin; Jing Chen; Yuanbin Zhang; Lin Dong; Xinhui Zhang; Xueyan Fu Abstract: Rosemary is an aromatic evergreen shrubby herb that is native to the Mediterranean region. This herb is now widely cultivated in many regions of the world. Rosemary is widely used in traditional Chinese medicines, foods, nutraceuticals and cosmetics. Hydro distilled essential oils, obtained from rosemary in China and the Mediterranean region, were analysed by gas chromatography-mass spectrometry (GC–MS). Thirty-seven compounds accounting for 94.97%-99.72% of the oils were identified. The majority of the compounds in the essential oils exhibited no significant differences (table 1 and fig. 1). The extracts were prepared with three solvents of different polarity (dichloromethane, ethyl acetate and aqueous). The ethyl acetate fractions exhibited the highest phenol content and were found to be significantly more active than the dichloromethane and aqueous fractions (fig. 2). Antioxidant activity (by DPPH radical scavenging, ferric ion reduction (FRAP) and thiobarbituric acid reactive substance (TBARS)) was also assessed. The ethyl acetate extracts of Yunnan had the highest amount of antioxidant capacity from China by DPPH and TBARS, with the lowest IC50 values being 0.0011 mg/ml, and 1.6611 mg/ml, respectively. In conclusion, the antioxidant activities of the essential oils and ethyl acetate extracts from rosemary obtained by three different testing methods revealed higher antioxidant activity from rosemary grown in China than in the Mediterranean region. These results suggested that Chinese rosemary should be widely used in food, traditional medicine, cosmetics and perfume products, as well as other chemical industries.

2018-01-20T00:00:00Z Muhammad Mukhtiar Syed Umer Jan Khan, Muhammad Farid Naseem Ullah Abid Hussain Saif ur Rehman Qureshi, Muhammad Murtaza http://localhost:80/xmlui/handle/123456789/15289 2022-12-19T10:27:19Z 2018-01-20T00:00:00Z

Title: Palladium glutathione, N-acetylcysteine, D-penicillamine conjugation chemistry Authors: Muhammad Mukhtiar; Syed Umer Jan; Khan, Muhammad Farid; Naseem Ullah; Abid Hussain; Saif ur Rehman; Qureshi, Muhammad Murtaza Abstract: The metalloelement Palladium has a number of potential Pharmaco-clinical advantages. Palladium compounds have antiviral, antibacterial, neuroprotective and antitumor properties. However studies have also indicated some mild to serious toxic effects of Palladium metalloelements. Biothiols are important antioxidants that provide protection against metals toxicity. The interaction of metalloelements with biothiols can provide valuable information about the level of toxicity of the metalloelements and about the protective role of biothiols thereof. In this piece of work the effect of salt and complexes of Palladium on the status of different thiols (GSH, NAC, and D-Pen) in aqueous medium, were examined, The thiol quantification was carried out using Elman’s method through UV-visible spectrophotometry and 1H- NMR. Results of the study performed in aqueous medium showed that level of different thiols depleted after the addition of the inorganic salts and organic complexes of Palladium. The mechanism of interaction of Palladium with thiols was examined using H-NMR. The results indicate that the depletion in the level of thiols may be due to 1:1 or 1:2 conjugation of Palladium with thiols. These conjugation reactions further suggest that the Palladium have xenobiotic nature causing oxidative stress and thiols play their role in detoxification and biotransformation of these metalloelements.

2018-01-20T00:00:00Z