http://localhost:80/xmlui/handle/123456789/16549 2026-02-23T19:02:31Z 2026-02-23T19:02:31Z D J Haleem http://localhost:80/xmlui/handle/123456789/16648 2023-01-23T10:17:30Z 1993-01-12T00:00:00Z

Title: Serotonergic neurotransmission in the regulation of appetite: a receptor approach Authors: D J Haleem Abstract: Neurochemical research on brain 5-hydroxytryptamine (5-HT; serotonin) and feeding shows that rat brain serotonin metabolism is increased following ingestion of a carbohydrate rich diet to generate a neurochemical signal for the termination of meal. Increased metabolism may not necessarily enhance postsynaptic function; neuropharmacological studies therefore gained attention. Drugs which mimick 5-HT function at the post synaptic sites have been shown to decrease feeding in experimental animals. Moreover some 5-HTergic drugs are potent anorectic agents. Multiple receptors for 5-HT exist in the central nervous system. Drugs with selectivity towards 5-HT-1B/ 5-HT-1C sites produced hypophagia, while 5-HT-1A selective drugs increased food intake. Studies designed to investigate sensitivity of these receptors following starvation or satiety may prove useful to develop drugs for therapeutic purposes.

1993-01-12T00:00:00Z J M Alam R Qasim http://localhost:80/xmlui/handle/123456789/16647 2023-01-23T10:17:11Z 1993-01-11T00:00:00Z

Title: Changes in serum components induced by venoms of marine animals Authors: J M Alam; R Qasim Abstract: Serum enzyme and chemical component levels were investigated in a rat model after experimental envenomation by venoms of coelentrate, Physalia species, four sea-snakes, Hydrophis spiralis, H. Cyanocinctus, H. Lapemoides and Lapemis curtus and a gastropod molluse Conus coronatus. The LD(50)s through i.v. route were found to be 4.2 mg/kg for Physalia, 0.4 mg/kg for H.spiralis 0.60 mg/kg for H.cyanocinctus, 0.60 mg/kg for H. lapemoides, 0.70 mg/kg for L.curtus and 2.9 mg/kg for C.coronatus. Marked elevation of serum enzyme levels was induced by sea-snake and Physalia venom while C.coronatus venom showed no significant change in serum levels. The results also indicate gross morphological changes in liver, spleen, gall bladder, lungs and heart by Physalia and sea snake venoms.

1993-01-11T00:00:00Z A Sher A Rahman http://localhost:80/xmlui/handle/123456789/16646 2023-01-23T10:14:08Z 1993-01-10T00:00:00Z

Title: Effect of rifampicin on the enterohepatic recycling of estrogen in female tuberculous patients Authors: A Sher; A Rahman Abstract: Enterohepatic recycling of estrogen after oral administration of 1 mg non-radioactive estriol was studied in ten women taking rifampicin as one of the antitubercular drugs and in fourteen healthy women selected as control subjects. The extent of enterohepatic recycling of estriol (E(3)) during early follicular phase of menstrual cycle was assessed by monitoring for 48 hours the urinary excretion of its two major metabolites i.e., estriol-16alpha-glucuronide (E(3)-16alpha-G) and estriol-3-glucuronide (E(3)-3-G). Of these metabolites the former is synthesized in liver as well as in the gut where as later is synthesized exclusively in the gut, hence the change in urinary level of H(3)-3-G with respect to E(3)-16alpha-G was considered to reflect the extent of enterohepatic recycling of E(3). The levels of both metabolites in urine were determined by radioimmunoassay. Lower values of variables including E(3)-3-G output, E(3)-3-G output as % of the total (E(3)-16alpha-G + E(3)-3-G) excretion and total E(3) (E(3)-16alpha-G + E(3)-3-G) output as % dose and the diurnal variation in urinary excretion of these metabolites show that the final elimination of E(3) from the body was quicker in these patients as compared with the control subjects, probably due to the reduced extent of enterohepatic recycling of E(3) as a result of long term chemotherapy with rifampicin.

1993-01-10T00:00:00Z S N Ali S U Kazmi N Akhtar A Malik http://localhost:80/xmlui/handle/123456789/16645 2023-01-23T09:51:06Z 1993-01-09T00:00:00Z

Title: An antitumor cardenolide with inhibitory activity against pseudomonas pseudomallei Authors: S N Ali; S U Kazmi; N Akhtar; A Malik Abstract: The antibacterial activity of a new cardenolide, 7beta, 14beta - dihydroxy-5-card-20(22) enolide has been studied and it has been found to be active against Pseudomonas pseudomallei. The new cardenolide also exhibited antitumor activity in a potato disc assay.

1993-01-09T00:00:00Z