http://localhost:80/xmlui/handle/123456789/14118 2026-04-24T02:57:11Z http://localhost:80/xmlui/handle/123456789/14221 Title: EVALUATION OF ANTIGLYCOSIDASE AND ANTICHOLINESTERASE ACTIVITIES OF BOEHMERIA NIVEA Authors: SANCHETI, SANDESH; SANCHETI, SHRUTI; SEO, SUNG-YUM Abstract: In this era, major community worldwide is suffering from diabetes type II, cancer and neurodegenerative disorders. To overcome these diseases, in the screening of Korean medicinal plants, we studied the whole plant of Boehmeria nivea (B. nivea). The methanolic leaf, stem and root extracts of B. nivea and their respective nhexane, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (BuOH) and aqueous fractions were investigated for their total phenolic content (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, α-glucosidase, β-glucosidase, α-galactosidase, β-galactosidase, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme inhibition activities. Profound TPC and DPPH free radical scavenging activities were observed in the EtOAc and BuOH fractions of root, where the BuOH fraction showed high-pitched α-glucosidase inhibition and the EtOAc layer showed the maximum β-glucosidase inhibition. Furthermore, the leaf extract demonstrated the highest β-galactosidase inhibitory activity, but no αgalactosidase inhibition was seen in any of the plant parts. Notable BChE and moderate AChE inhibitory activity was found in whole plant. It can be suggested that whole plant of B. nivea provides a strong biochemical rationale as one of the good choices for the treatment of diabetes type II, cancer and neurodegenerative diseases (AD, etc). 2010-04-20T00:00:00Z http://localhost:80/xmlui/handle/123456789/14219 Title: FORMULATION AND EVALUATION OF CETIRIZINE DIHYDROCHLORIDE ORODISPERSIBLE TABLET Authors: SUBRAMANIAN, S; SANKAR, V; MANAKADAN, ASHA ASOKAN; ISMAIL, SAREENA; ANDHUVAN, G Abstract: Cetirizine orodispersible tablets were prepared to achieve quick onset of action and for maximum bioavailability. Tablets were prepared using cetirizine along with camphor and mannitol in the proportion of 1:1:1, 1:1:3, and 1:1:6. The flow property of granules was found to be good for the formulation CZ2 (1:1:3). The hardness and friability of all the formulations were found to be within the standard limit for orodispersible tablets. Disintegration time was found to be rapid in formulation CZ2 (1:1:3).The in vitro dissolution time was found to be 100% in 11 minutes for the formulation CZ2 (1:1:3). 2010-04-19T00:00:00Z http://localhost:80/xmlui/handle/123456789/14218 Title: ANTIMICROBIAL EFFECTS OF BOESENBERGIA PANDURATA AND PIPER SARMENTOSUM LEAF EXTRACTS ON PLANKTONIC CELLS AND BIOFILM OF ORAL PATHOGENS Authors: TAWEECHAISUPAPONG, SUWIMOL; SINGHARA, SUPAPORN; LERTSATITTHANAKORN, PILANTHANA; KHUNKITTI, WATCHAREE Abstract: Increasing awareness of hazards associated with the use of antibiotic and chemical agents has accelerated investigations into plants and their extracts as new sources of antimicrobial agents. Therefore, this study aimed at determining the effects of oil and 95% ethanol extracts of Boesenbergia pandurata rhizomes and Piper sarmentosum leaf against four oral pathogens which were Streptococcus mutans, Lactobacillus sp., Aggregatibacter actinomycetemcomitans and Candida albicans. Employing the disc diffusion and broth microdilution methods, the results showed that B. pandurata oil (BPO) was the most effective extract against C. albicans. Time-kill assay with the BPO demonstrated killing of C. albicans at concentrations equal to 2 and 2.5 times the MIC. The times required to reach the fungicidal endpoint at 2 and 2.5 times the MIC were 60 and 44 min, respectively. In addition, our results also demonstrated that the BPO possesses potent anti- Candida biofilm activity in vitro. Therefore, the BPO could be considered as a natural antifungal agent against Candida infections and has significant potential for further investigation. 2010-04-18T00:00:00Z http://localhost:80/xmlui/handle/123456789/14216 Title: SYNTHESIS OF SOME NOVEL ANALOGUES OF 4-(1-PYRROLIDINYL) PIPERIDINE AND THEIR EFFECT ON PLASMA GLUCOSE LEVEL Authors: MUSHTAQ, NOUSHEEN; SAIFY, Z.S; AKHTAR, SHAMIM; ARIF, MUHAMMAD; HAIDER, SAIDA; SABA, NAZISH Abstract: In the present study some compounds of 4-(1-Pyrrolidinyl) Piperidine (I) have been synthesized. Structures of compounds were confirmed by using HNMR, IR, Mass and UV spectrophotometer techniques. All the derivatives (II, III, IV and V) and the parent compound (I) at the dose of 100 mg/kg were evaluated for their effect on plasma glucose level. Compound (II) was the only derivative which showed effect on plasma glucose level. 2010-04-17T00:00:00Z