http://localhost:80/xmlui/handle/123456789/14239 2026-04-23T17:14:31Z http://localhost:80/xmlui/handle/123456789/16451 Title: REVIEW DOES VITAMIN E HAVE A ROLE IN TREATMENT AND PREVENTION OF ANEMIA’S? Authors: TANVEER JILANI; MOHAMMAD PERWAIZ IQBAL Abstract: Vitamin E is a highly effective fat-soluble vitamin with a variety of cellular membrane stabilizing-antioxidant and non-antioxidant functions. Vitamin E has been suggested to prevent the oxidation of polyunsaturated fatty acids in red blood cell (RBC) membrane, thus inhibiting the premature erythrocytelysis. Animal studies have shown that treatment with vitamin E results in increased number of colony forming units of erythroid precursors, enhanced erythropoiesis and improved blood hemoglobin levels in these animals. Several clinical trials have indicated that vitamin E might be used therapeutically as a potential erythropoietic agent for decreasing the premature erythrocyte hemolysis by reducing the fragility of erythrocytes. By this way, it improves the post-supplemental blood hemoglobin and hematocrit levels in some of the anemic human subjects, including low birth weight premature infants, patients suffering from various types of inherited hemolytic anemia, chronic renal failure patients on hemodialysis and apparently healthy mildly anemic subjects. 2011-04-23T00:00:00Z http://localhost:80/xmlui/handle/123456789/16450 Title: SHORT COMMUNICATION INVESTIGATION OF HYPERICUM PERFORATUM EXTRACT ON CONVULSION INDUCED BY PICROTOXIN IN MICE Authors: ETEMAD, LEILA; MAHMOUD REZA HEIDARI; MOHAMMAD HEIDARI; MOHAMMAD MOSHIRI; BEHRAVAN, EFFAT; ABBASIFARD, MITRA; AZIMZADEH, BEHZAD SARVAR Abstract: Therapeutic effect of Hypericum perforatum L. has been well known. The aim of this study is to investigate the anticonvultant effects of Hypericum methanolic extract against seizure induced by picrotoxin in mice. The study were performed on four groups of animals. They received percolated extract of Hypericum perforatum at the doses of 25, 50, 100 & 200 mg/kg intra peritoneally. After 20 minutes animals received picrotoxin 10 mg/kg for induction of seizure. Latency of seizure, duration of seizure, death latency and percent of mortality were determined. The results indicated that latency of seizure increased in pretreated group with the dose of 50 mg/kg (p<0.01). The higher dose of extract 200 mg/kg significantly decrease duration of seizure and death latency. It maybe due to unknown ingredients in this plant or producing concentrations higher than the therapeutic level. The results showed that Hypericum perforatum L. at the dose of 50 mg/kg maybe have some beneficial effect in seizure induced by picrotoxin and this plant is suitable for continuing search in this field. 2011-04-22T00:00:00Z http://localhost:80/xmlui/handle/123456789/16449 Title: REPORT TREATMENT OF NIGELLA SATIVA IN EXPERIMENTAL SEPSIS MODEL IN RATS Authors: ALICI, OZLEM; KAVAKLI, HAVVA SAHIN; KOCA, CEMILE; ALTINTAS, NERIMAN DEFNE Abstract: This experimental study was designed to determine effects of Nigella sativa oil (NSO) on endothelin-1 (ET-1) level and oxidative stress parameters, superoxide dismutase (SOD) and malondialdehyde (MDA) in a rat sepsis model. Twenty four adult Wistar albino rats were divided randomly into three groups: sham group (group 1), sepsis group (group 2), sepsis group pretreated with NSO (group 3). Serum ET-1, tissue SOD and tissue MDA levels were measured in all groups. Compared to group 1, ET-1 and MDA levels were higher in group 2. ET-1 and MDA levels in NSO pretreated group 3 were lower with respect to group 2 (p<0.03, and p<0.02, respectively). Additionally, SOD levels in group 3 were found to be higher than group 2 (p<0.02). Based on our results, it can be concluded that NSO may have a positive impact on ET-1 levels and oxidative stress induced by sepsis in experimental rat models. 2011-04-21T00:00:00Z http://localhost:80/xmlui/handle/123456789/16448 Title: ANTI LIPID PEROXIDATION ACTIVITY OF PIPER TRIOICUM ROXB. AND PHYSALIS MINIMA L. EXTRACTS Authors: DINAKARAN, SATHIS KUMAR; SARASWATHI, NARASIMHA RAJU; RAO NALINI, VENKATA RAMA; SRISUDHARSON; BODANAPU, VENKAT RAM REDDY; HARANI AVASARALA; DAVID BANJI Abstract: Attempt has been made to evaluate free radical scavenging activity of ethanolic extract of Piper trioicum Roxb. and Physalis minima L. individually. In this study goat liver has been used as lipid source. This in vitro evaluation was done by measuring the malondialdehyde (MDA) of tissue homogenates. The results suggest that the ethanolic extract of the Piper trioicum Roxb. and Physalis minima L. has the ability to suppress the lipid peroxidation and it was also found that Piper trioicum Roxb. extract has more activity than Physalis minima L. extract. 2011-07-20T00:00:00Z