http://localhost:80/xmlui/handle/123456789/14243 2026-04-18T13:29:09Z http://localhost:80/xmlui/handle/123456789/16451 Title: REVIEW DOES VITAMIN E HAVE A ROLE IN TREATMENT AND PREVENTION OF ANEMIA’S? Authors: TANVEER JILANI; MOHAMMAD PERWAIZ IQBAL Abstract: Vitamin E is a highly effective fat-soluble vitamin with a variety of cellular membrane stabilizing-antioxidant and non-antioxidant functions. Vitamin E has been suggested to prevent the oxidation of polyunsaturated fatty acids in red blood cell (RBC) membrane, thus inhibiting the premature erythrocytelysis. Animal studies have shown that treatment with vitamin E results in increased number of colony forming units of erythroid precursors, enhanced erythropoiesis and improved blood hemoglobin levels in these animals. Several clinical trials have indicated that vitamin E might be used therapeutically as a potential erythropoietic agent for decreasing the premature erythrocyte hemolysis by reducing the fragility of erythrocytes. By this way, it improves the post-supplemental blood hemoglobin and hematocrit levels in some of the anemic human subjects, including low birth weight premature infants, patients suffering from various types of inherited hemolytic anemia, chronic renal failure patients on hemodialysis and apparently healthy mildly anemic subjects. 2011-04-23T00:00:00Z http://localhost:80/xmlui/handle/123456789/16450 Title: SHORT COMMUNICATION INVESTIGATION OF HYPERICUM PERFORATUM EXTRACT ON CONVULSION INDUCED BY PICROTOXIN IN MICE Authors: ETEMAD, LEILA; MAHMOUD REZA HEIDARI; MOHAMMAD HEIDARI; MOHAMMAD MOSHIRI; BEHRAVAN, EFFAT; ABBASIFARD, MITRA; AZIMZADEH, BEHZAD SARVAR Abstract: Therapeutic effect of Hypericum perforatum L. has been well known. The aim of this study is to investigate the anticonvultant effects of Hypericum methanolic extract against seizure induced by picrotoxin in mice. The study were performed on four groups of animals. They received percolated extract of Hypericum perforatum at the doses of 25, 50, 100 & 200 mg/kg intra peritoneally. After 20 minutes animals received picrotoxin 10 mg/kg for induction of seizure. Latency of seizure, duration of seizure, death latency and percent of mortality were determined. The results indicated that latency of seizure increased in pretreated group with the dose of 50 mg/kg (p<0.01). The higher dose of extract 200 mg/kg significantly decrease duration of seizure and death latency. It maybe due to unknown ingredients in this plant or producing concentrations higher than the therapeutic level. The results showed that Hypericum perforatum L. at the dose of 50 mg/kg maybe have some beneficial effect in seizure induced by picrotoxin and this plant is suitable for continuing search in this field. 2011-04-22T00:00:00Z http://localhost:80/xmlui/handle/123456789/16449 Title: REPORT TREATMENT OF NIGELLA SATIVA IN EXPERIMENTAL SEPSIS MODEL IN RATS Authors: ALICI, OZLEM; KAVAKLI, HAVVA SAHIN; KOCA, CEMILE; ALTINTAS, NERIMAN DEFNE Abstract: This experimental study was designed to determine effects of Nigella sativa oil (NSO) on endothelin-1 (ET-1) level and oxidative stress parameters, superoxide dismutase (SOD) and malondialdehyde (MDA) in a rat sepsis model. Twenty four adult Wistar albino rats were divided randomly into three groups: sham group (group 1), sepsis group (group 2), sepsis group pretreated with NSO (group 3). Serum ET-1, tissue SOD and tissue MDA levels were measured in all groups. Compared to group 1, ET-1 and MDA levels were higher in group 2. ET-1 and MDA levels in NSO pretreated group 3 were lower with respect to group 2 (p<0.03, and p<0.02, respectively). Additionally, SOD levels in group 3 were found to be higher than group 2 (p<0.02). Based on our results, it can be concluded that NSO may have a positive impact on ET-1 levels and oxidative stress induced by sepsis in experimental rat models. 2011-04-21T00:00:00Z http://localhost:80/xmlui/handle/123456789/16447 Title: REPORT IN VIVO ANTIOXIDANT ACTIVITY OF ZATARIA MULTIFLORA BOISS ESSENTIAL OIL Authors: FARIBA SHARIFIFAR; AMIN DERAKHSHANFAR; DEHGHAN-NUDEH, GHOLAMREZA; ABBASI, NAJMA; ABBASI, REZA; GHARAEI, REZA REZAEI; KOOHPAYEH, ABED; DANESHPAJOUH, MOHAMMAD Abstract: Zataria multiflora Boiss. (Lamiaceae) is an endemic plant to Iran with many traditional uses. We have reported previously in vitro antioxidant activity of the essential oil of the plant. In the present work we aimed to evaluate the antioxidant activity of the oil in rat. Antioxidant activity was measured by the test of 1,1-diphenyl-2- picrylhydrazyl (DPPH) radical inhibition and inhibition of lipid peroxidation by measuring the index of thiobarbituric acid reactive substances (TBARs). Three doses of 100, 200 and 400 µL/ kg of the essential oil of Z. multiflora (ZMO) was administered to animals by i.g routh for 10 days. The blood was collected in 11th day through direct puncture and the liver was rapidly excised. The histopathology studies of the animals was compared to animals in butylated hydroxyl toluene (BHT) group. The results showed that ZMO in all tested doses significantly was able to scavenge DPPH radical (p<0.05). ZMO also decreased TBARs in a dose dependent manner. No alteration in LFT enzymes or changes in histopathology of the liver was considered in ZMO treated groups. The results indicated that ZMO might be used in healthy medicine and food industry. 2011-04-20T00:00:00Z