http://localhost:80/xmlui/handle/123456789/14244 2026-04-23T18:56:53Z http://localhost:80/xmlui/handle/123456789/16448 Title: ANTI LIPID PEROXIDATION ACTIVITY OF PIPER TRIOICUM ROXB. AND PHYSALIS MINIMA L. EXTRACTS Authors: DINAKARAN, SATHIS KUMAR; SARASWATHI, NARASIMHA RAJU; RAO NALINI, VENKATA RAMA; SRISUDHARSON; BODANAPU, VENKAT RAM REDDY; HARANI AVASARALA; DAVID BANJI Abstract: Attempt has been made to evaluate free radical scavenging activity of ethanolic extract of Piper trioicum Roxb. and Physalis minima L. individually. In this study goat liver has been used as lipid source. This in vitro evaluation was done by measuring the malondialdehyde (MDA) of tissue homogenates. The results suggest that the ethanolic extract of the Piper trioicum Roxb. and Physalis minima L. has the ability to suppress the lipid peroxidation and it was also found that Piper trioicum Roxb. extract has more activity than Physalis minima L. extract. 2011-07-20T00:00:00Z http://localhost:80/xmlui/handle/123456789/16444 Title: ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF ETHANOLIC EXTRACT OF SPHAERANTHUS INDICUS LINN Authors: ADAM ALI; NAQVI, SYED BAQIR SHYUM; SHAHNAZ GAUHAR; REHANA SAEED Abstract: The aim of the present study was to evaluate the intensity of the anti-inflammatory and analgesic activities of Sphaeranthus indicus on albino mice and rat of either sex. The flowers of S. indicus are an important herb used in folk eastern medicines. In this study, the ethanolic extract of S. indicus in doses of 300 and 500 mg/kg was used. Anti-inflammatory activity was evaluated by measuring the mean decrease in hind paw volume after the sub planter injection of carrageenan. The analgesic activity was tested against acetic acid induced writhing response using albino rats. Result of the study shows that at the end of one hour the inhibition of paw edema was 42.66 and 50.5% respectively and the percentage of protection from writhing was 62.79 and 68.21 respectively. S. indicus possesses several important pharmaceutical and pharmacological properties. The current study describes that flower of S. indicus has significant anti-inflammatory and analgesic properties. Conclusion of the study is that this herbal medicine can be used as an alternative therapy for the treatment of minor to moderate types of inflammation and as a painkiller 2011-07-20T00:00:00Z http://localhost:80/xmlui/handle/123456789/16441 Title: FORMULATION AND EVALUATION OF FICUS GLOMERATA MUCILAGE SUSTAINED RELEASE MATRIX TABLETS OF GLICLAZIDE Authors: AHAD, HINDUSTAN ABDUL; KUMAR, CHITTA SURESH; BUDIDET, KISHORE KUMAR REDDY; BATTULA, SUMA PADMAJA; AYYAVALA, CHANDRA SEKHAR Abstract: The main aim of present investigation was to develop sustained release matrix tablets of Gliclazide using fruit mucilage from the plant Ficus glomerata. Varying ratios of drug and polymer viz. 1:0.25, 1:0.5, 1:0.75, 1:1.0 and 1:1.25 were selected for the study. The flow properties of powdered mucilage and physical properties of matrix tablets were performed. The swelling behavior and release rate characteristics were studied. The in vitro drug release data was analyzed by zero order, first order, Higuchi plot, Peppas plot and Hixon-Crowell Models. It was observed that as the proportion of mucilage increased the release of drug from the matrix tablets was retarded. Stability studies were conducted at 40±2ºC and RH 75±5% for 3 months indicates that Gliclazide was stable in the matrix tablets. The Differential Scanning Calorimetric (DSC) and Fourier Transform Infrared (FTIR) study revealed that there was no negative chemical interaction between drug and the mucilage used. From the dissolution study, it was concluded that dried Ficus glomerata mucilage can be used as an excipient for making sustained release matrix tablets. 2011-07-20T00:00:00Z http://localhost:80/xmlui/handle/123456789/16438 Title: EFFECT OF NATURAL HONEY ON HUMAN PLATELETS AND BLOOD COAGULATION PROTEINS Authors: ASIF AHMED; KHAN, RAFEEQ ALAM; AZIM, M. KAMRAN; SAEED, S. ARSHAD; MESAIK, M. AHMED; SHAKIL AHMED; IMRAN IMRAN Abstract: Present study was conducted to determine the effects of honey on blood hemostasis, in-vitro effect of honey was observed on platelet aggregation and blood coagulation employing, activated partial prothrombin time (aPTT), prothrombin time (PT), thrombin time (TT) and fibrinogen levels in blood. Honey samples showed moderate inhibition of platelet aggregation with IC50 5-7.5%. The coagulation assays showed that at higher concentrations (≥15%) honey samples increased whole blood clotting time. When assayed in platelet poor plasma (PPP), honey samples significantly (P≥0.005) prolonged aPTT, PT, and TT. The honey samples (at 3.75% and 7.5% concentrations) cause mean increment of aPTT = 19±10% and 62±10%; PT 6±5% and 40±5%; TT 35±15% and 112±30% respectively. Moreover, PPP isolated from whole blood pre-incubated with honey samples (9.0% for 10 minutes) showed mean prolongation of aPTT, PT and TT of 45±21%, 26±9% and 105±24% respectively. Interestingly, incubation of honey at 6.25% and 11.75% concentrations in PPP considerably (P≥0.005) reduced fibrinogen levels i.e. 13±4% and 86±30% respectively. The present study outlines the inhibitory effect of natural honey on platelet aggregation and blood coagulation. These observations provide first line data for modulatory role(s) of honey on process of hemostasis. 2011-07-20T00:00:00Z