http://localhost:80/xmlui/handle/123456789/14254 2026-02-25T14:31:51Z http://localhost:80/xmlui/handle/123456789/15165 Title: A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro Authors: Gamal, Ali Ali El; El Halim, Mohamed Farag Abd; Kalil, Ashraf Taha; Basudan, Omer Ahmed; Al-Rehaily, Adnan Jathlan; Ahmad, Mohamed Shamim; El Tahir, Kamal Hussin; Al-Massarani, Shaza Mohamed; Abdel-Mageed, Wael Moustafa Abstract: A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs’ platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β- amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin. 2015-03-15T00:00:00Z http://localhost:80/xmlui/handle/123456789/15164 Title: Expression of Cripto-1 gene protein and Activin-A in human lung adenocarcinoma tissue Authors: Shan, Yangyang; Li, Shenglei Abstract: To research the expression in human lung adenocarcinoma tissue of Cripto-1 (teratocarcinoma derived growth factor-1) gene protein and Activin-A gene protein, and explore the relationship and clinical significance between the two gene protein and clinical pathological characteristic of lung adenocarcinoma. This study had applied the immunohistochemical method to detect the 188 cases of lung adenocarcinoma and expression of Cripto-1 protein and Activin-A protein in 100 cases of normal lung tissue. Then, analysis the relationship between these two-gene protein and clinical lung adenocarcinoma histopathological features, and inherent correlation between these two genes. The positive expression rate of Cripto-1 protein in lung adenocarcinoma tissue was significantly higher in normal lung tissue, while, the positive expression rate of Activin-A protein in lung adenocarcinoma tissue was significantly lower than in normal lung tissue. The high expression of Cripto-1 and low expression of Activin-A was closely related (each P<0.05) to the TNM staging of lung adenocarcinoma, lymph node metastasis and the main pathological tissue staging of lung adenocarcinoma. And the correlation analysis showed that it was negative correlation for the expression of Activin-A protein and Cripto-1 protein in lung adenocarcinoma. The over expression of Cripto-1 and the expression lack of Activin-A were correlated with the occurrence, development, metastasis and malignant degree of lung adenocarcinoma. 2015-03-14T00:00:00Z http://localhost:80/xmlui/handle/123456789/15163 Title: The optimization research of the multi-response problems based on the SUR Authors: Su, Haitao; Yao, Hong Mei; Zeng, Hui Abstract: In the optimization design of products and processes in the biological medicine, we need to consider multiple characteristics of quality simultaneously, namely multi-response problems, multi-response optimization design can improve the quality of the products effectively, and realize enormous economic benefits and so multi-response optimization design is showing a more and more important role in continuous quality improvement activities. But usually there is no specific set of input variables to make all the response variables be optimal, and the traditional multiresponse surface method cannot solve the correlation problem between multi-responses and regression model problem effectively. Because we can make a better fitting model and solve the problem of the correlation between the response variables at the same time with SUR method, this thesis uses the SUR method to model the relationship between each response and control variables, and makes predictions; confirms the satisfaction function of each response and the overall satisfaction function; combines with practical problems of a company in biological medicine field named SX to conduct empirical research, this thesis confirms the optimal factor level combination with the overall satisfaction function in the end, thus solves the multi-response optimization problems. 2015-03-13T00:00:00Z http://localhost:80/xmlui/handle/123456789/15161 Title: Nursing and safety of silver needle diathermy treating ankylosing spondylitis Authors: Ning, Huaxiu; Wang, Yun; Yuan, Yiwen; Ning, Huaying Abstract: This paper aims to discuss the nursing and safety of silver needle diathermy in the treatment for ankylosing spondylitis. We nursed 46 patients with ankylosing spondylitis treated with silver needle diathermy. Specific nursing was focused on physical condition evaluation and mental nursing before treatment, observation during and after treatment, diet nursing, needle eye nursing, functional training and propaganda and education when discharged. The result suggested that all the patients received mental nursing, diet guide, skin care, health education, functional training and follow-up visit from the nurse and all of them could endure silver needle diathermy as discomfort or drug allergy was barely found, so were slight scald and skin infection nearby the needle eye caused by fainting during acupuncture, accidental puncture or overheat. Follow-up visit showed that no patient suffered obvious untoward effect and the pain, joint range of motion and living condition were distinctly improved a week after discharging. In conclusion, during the treatment for ankylosing spondylitis applying silver needle diathermy, the nursing before, during and after the treatment can obviously reduce the complication, accelerate the recovery, which is highly safe. 2015-03-12T00:00:00Z