http://localhost:80/xmlui/handle/123456789/14334 2026-04-22T11:11:08Z http://localhost:80/xmlui/handle/123456789/16290 Title: Assessment of Feng-Liao-Chang-Wei-Kang as a potential inducer of cytochrome P450 3A4 and pregnane X receptors Authors: Xie, Yiqiang; Li, Yuhua; Huang, Mianqing; Wu, Qing; Liu, Qibing; Zhang, Junqing; Deng, Huiming; Liu, Mi; Huang, Ling Abstract: Feng-Liao-Chang-Wei-Kang (FLCWK), a traditional Chinese patent medicine, consists primarily of Polygonum hydropiper and Daphniphyllum calycinum roots. As a complex containing several kinds of flavonoids, FLCWK has the potential to impact the drug metabolism enzyme P450 3A4 (CYP3A4) and nuclear receptors. The purpose of this research was to probe the effects of FLCWK on CYP3A1, the homolog of CYP3A4 in rats, and to confirm whether FLCWK interferes with PXR and CAR-mediated transactivation of CYP3A4. The effects of FLCWK on Cyp3a1 mRNA, catalytic activity levels, and protein expression in Sprague-Dawley (SD) rat liver tissues were examined using real-time PCR, western blotting, and high-performance liquid chromatography (HPLC) assays, respectively. The efficacy of PXR and CAR on CYP3A4 transcriptional activity were detected using luciferase reporter assays and further research of the impact of FLCWK on CYP3A4 gene expression mediated by the PXR pathway was examined by transient transfection of PXR siRNA. FLCWK significantly increased Cyp3a1 mRNA, CYP3A1 activity, and protein expression levels in SD rats. FLCWK highly induced CYP3A4 luciferase activity mediated by PXR in PXRCYP3A4 co- transfected cells. A siRNA-mediated drop-off in PXR expression greatly cut the effect of FLCWK on CYP3A4 mRNA expression in HepG2 cells. These findings show that FLCWK up-regulates CYP3A4 levels via the PXR pathway. This effect should be considered being applied in clinical use as FLCWK has the potential to interact with other drugs. 2018-09-24T00:00:00Z http://localhost:80/xmlui/handle/123456789/16288 Title: Effect of different doses of ulinastatin on cellular immunity and hepatorenal functions in patients undergoing laparoscopic colorectalcarcinoma surgery Authors: Ji, Zhiwu; Tian, Hao; Shang, Jincai; Liu, Wensi; Zhong, Min; Chen, Zhendong Abstract: The effect of different doses of ulinastatin on cellular immunity and hepatorenal functions in patients undergoing laparoscopic colorectal-carcinoma surgery was observed and analyzed. The 200 patients with laparoscopic colorectal-carcinoma surgery in our hospital were selected as research subjects and divided into 4 groups containing equal patients, namely, saline group, 0.5 x 104U/kg ulinastatin group, 1 x 104U/kg ulinastatin group, and 1.5 x 104U/kg ulinastatin group, which were denoted as group A, group B, group C and group D, respectively. The treatment effect of patients in 4groups was observed and compared. By observing the Narcotrend cerebral state index (NT index), the results showed that NT index at tracheal intubation, pneumoperitoneum beginning, pneumoperitoneum 30min, resection of tumor, end of operation in 4 groups was significantly lower than that at preoperative anesthesia (T0) (p<0.05); differences in hepatorenal values (AST, ALT, BUN and Cr) among 4 groups at T0 were of no statistical significance (P > 0.05); each index in T cell subsets in the postoperative third days (T1) was significantly lower than that at T0; indexes of T cell subgroup of group B, C and D at T1 were higher than that of group A at T1 (p<0.05). For 4 groups, the difference in liver and kidney function indicators at T1 and T0 was of no statistical significance, p>0.05. Different doses of ulinastatin have a certain effect on cellular immunity in patients undergoing laparoscopic colorectal-carcinoma surgery and do not significantly affect hepatorenal function. 2018-09-23T00:00:00Z http://localhost:80/xmlui/handle/123456789/16287 Title: Observation on efficacy for rectal medication of methyl carprost suppository combined with oxytocin in preventing hemorrhage after cesarean section Authors: Ling, Li; Ma, Shaoping; Li, Ranran Abstract: The efficacy for rectal medication of methyl carprost suppository combined with oxytocin in preventing and controlling hemorrhage after cesarean section is observed and analyzed. The 180 parturients who are conducted cesarean section in our hospital are selected as research subjects. All parturients are entitled to the right to know and randomly divided into research group and control group with 90 cases in each group. Among them, the parturients in control group are given oxytocin to prevent and control hemorrhage during the operation, while the research group combines with rectal medication of methyl carprost suppository to prevent and control postoperative hemorrhage base on the ways of control group. The condition of hemorrhage in two groups is observed and compared. By comparing with the time of the third stage of labor in two groups, the results don’t demonstrate significant difference (p>0.05). Compared with the amount of hemorrhage during the operation, 2h and 24h after delivery, the amount of hemorrhage in research group is less than control group with obvious difference (p<0.05); through recording the change of blood pressure before and after medication in two groups, the result shows that there is no significant difference (p<0.05), which indicates higher safety. In preventing and controlling hemorrhage after cesarean section, rectal medication of methyl carprost suppository combining with oxytocin can achieve good efficacy, significantly reduce the amount of postpartum hemorrhage and will not affect the blood pressure index. 2018-09-22T00:00:00Z http://localhost:80/xmlui/handle/123456789/16286 Title: Comparison of clinical efficacy and safety between articaine and lidocaine in the anaesthesia management of tooth pulp disease Authors: Li, Junliang; Wei, Wei; Yang, Weidong; Li, Jingjing; Gao, Yafan; Qian, Yajie Abstract: To evaluate and compare the clinical efficacy and safety between articaine and lidocaine in the anaesthesia management of tooth pulp disease. The 160 patients with tooth pulp disease treated at our hospital were enrolled. After informed consent was obtained, patients were randomly assigned to study group and control group, with 80 patients in each group. Of those, lidocaine was administered to the control group while articaine was given to the study group. The onset time, analgesic effect and adverse events were recorded. Compared with control group, the onset time was significantly reduced in study group (p<0.05). Patients treated with articaine had better analgesic effect than patients in control group (p<0.05). And the incidence of adverse events was notably lower in study group (p<0.05). Compared with lidocaine, articaine presents higher analgesic efficacy and safety for patients with tooth pulp disease. 2018-09-21T00:00:00Z