http://localhost:80/xmlui/handle/123456789/14443 2026-04-24T07:34:50Z http://localhost:80/xmlui/handle/123456789/15111 Title: REVIEW Therapeutic potential of carbonic anhydrase inhibitors Authors: Rahman, Shafiq-ur-; Bib, Sumbal; Javed, Tariq; Alam, Fiaz; Atif Ali, Zia ur Rehman; Quresh, Sayyad; Ali, Majeed; Ullah, Muhammad Hassham Hassan Bin; Asad, Syed Muhammad; Hasan, Farid; Sabatier, Jean-Marc; Rizvanov, Albert A Abstract: Enzymes are biological catalyst involve in different biochemical reactions. But over activation of these biomolecules can cause disease thus different inhibitors and knockout therapies are use in current clinical practice. Carbonic anhydrases (CAs), a group of ubiquitously expressed metalloenzymes, are involved in numerous physiological and pathological processes, including gluconeogenesis, lipogenesis, ureagenesis, tumorigenicity and the growth and virulence of various pathogens. In addition to the established role of CA inhibitors (CAIs) as diuretics and antiglaucoma drugs, it has recently emerged that CAIs could have potential as novel anti-obesity, anticancer and anti-infective drugs. Furthermore, recent studies suggest that CA activation may provide a novel therapy for Alzheimer’s disease. This article discusses the biological rationale for the novel uses of inhibitors or activators of CA activity in multiple diseases, and highlights progress in the development of specific modulators of the relevant CA isoforms, some of which are now being evaluated in clinical trials 2019-04-02T00:00:00Z http://localhost:80/xmlui/handle/123456789/15107 Title: MINI REVIEW Wound healing potential of edible plants Authors: Katyakyini Muniandy; Sivapragasam Gothai; Palanisamy Arulselvan; Subbiah Suresh Kumar; Mohd Esa Norhaizan; Arthanari Umamaheswari; Sharida Fakurazi Abstract: Wound healing is a natural intricate cascade process involving cellular, biochemical and molecular mechanism to restore the injured or wounded tissue. Malaysia's multi-ethnic social fabric is reflected in its different traditional folk cuisines with different nutritional important ingredients. Despite these differences, there are some commonly used pantry ingredients among Malaysians and these ingredients may possess some healing power for acute and chronic wounds. These essential nutritional ingredients are included Amla (Ribes uva-crispa), Cinnamon (Cinnamomun venum), Curry Leaves (Murraya koenigii), Coriander (Coriandrum sativum), Fenugreek (Trigonella foenum-graecum), Garlic (Allium indica), Onion (Allium cepa) and Tamarind (Tamarindus indica). This article provides a review of the remedies with confirmed wound healing activities from previous experiments conducted by various researchers. Most of the researchers have focused only on the preliminary studies through appropriate model; hence detailed investigations which including pharmacological and pre-clinical studies are needed to discover its molecular mechanisms. In this review article, we have discussed about the wound healing potential of few commonly used edible plants and their known mechanism 2019-04-01T00:00:00Z http://localhost:80/xmlui/handle/123456789/15104 Title: REPORT Interactions and conflicts of interests between prescribers and medical sales representatives (MSRs) regarding prescribing and drug promotion practices in Karachi, Pakistan Authors: Naqvi, Atta Abbas; Zehra, Fatima; Khan, Nabeel; Ahmad, Rizwan; McGarry, Ken Abstract: Pharmaceutical drug promotion practices are found to have potentially controversial ethical standards. They may compromise on patient’s wellbeing especially when it inordinately affects the clinical care and patient’s interests by influencing the prescribing behavior of physicians. There is no proper system to keep a watch on the drug marketing and promotion strategies by the pharmaceuticals in Pakistan. A cross sectional study using a specially designed questionnaire and convenience sampling was conducted in Karachi for 6 months targeting prescribers and medical sales representative (MSRs). A total of 600 MSRs and prescribers consented to participate. 66% of MSRs highlighted that prescribers follow ethical prescribing but only (58%) seek evidence base behind promoted drug. This was contradictory to prescribers’ response to same, which was 87%. Only (10%) of prescribers acknowledged demanding expensive gifts such as laptops, ACs, furniture and renovation of the clinic which was about 40% according to MSRs. This study offered intricate insights into the MSR and physicians interactions. It highlighted various aspects of these relationships from both MSRs’ and prescribers’ point of view. Although majority of the physicians negated the notion of expecting expensive favors from the sales representatives, responses by MSRs suggest that anticipation of gifts and incentives exists on part of the physicians. This has the potential to indulge in unethical promotion and irrational prescribing on part of MSRs and prescribers respectively that may further contribute to untoward patient outcomes such as increased treatment costs and adverse drug reactions. 2019-03-31T00:00:00Z http://localhost:80/xmlui/handle/123456789/15102 Title: REPORT Laparoscopic management for coexistent parasitic ovarian teratoma of the omentum and ovarian mucinous cystadenoma: A case report Authors: Huang, Chen-Ching; Koh, Lim-Woh Abstract: We report a case of a 34-year-old woman who underwent laparoscopy for her adnexal tumor. Coexistence of ovarian mucinous cystadenoma and parasitic ovarian teratoma of the omentum was found and successfully treated by laparoscopic surgery. As our case presented, it is thought that the omental teratomas could be resulting from the autoamputation and re-implantation of a dermoid cyst of the ovary. 2019-03-29T00:00:00Z