http://localhost:80/xmlui/handle/123456789/14972 2026-04-10T20:38:56Z http://localhost:80/xmlui/handle/123456789/16536 Title: NEUROCHEMICAL AND BEHAVIOURAL EFFECTS OF LONG TERM INTAKE OF TEA Authors: SAIDA HAIDER; ANILA YASMEEN; TAHIRA PARVEEN; DARAKHSHAN J. HALEEM Abstract: Tea consumption in many cases is the main source of caffeine intake in humans. In the present study neurochemical and behavioural effects of long term tea intake are monitored in rats. Long term tea administration did not alter plasma tryptophan (TRP) but significantly attenuated brain TRP and 5-hydorxtryptamine (5-HT, serotonin) levels. Brain 5-hydroxyindole acetic acid (5-HIAA) was comparable in both tea-treated and control rats. An increase in home cage activity was observed after one week in rats taking tea as sole source of liquid, whereas no change on the activity was observed in an open field. Caffeinism has been associated with depression. The decreases of brain monoamine metabolism observed in present study are discussed as lowering of mood observed in tea or coffee consumers. 1998-07-08T00:00:00Z http://localhost:80/xmlui/handle/123456789/16535 Title: HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONSHIGH PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF ISONIAZID, PYRAZINAMIDE AND RIFAMPICIN IN PHARMACEUTICAL PREPARATIONS Authors: M.Y. KHUHAWAR; F.M.A. RIND Abstract: Isoniazid (IS) individually or in the presence of pyrazinamide and rifampicin has been determined by high performance liquid chromatography (HPLC) after derivatization with 6-methyl-2-pyridinecarboxaldehyde. Pyrazinamide and rifampicin separate completely from isoniazid derivative and are determined imultaneously. The chromatography is carried out from YMC-ODS column with elution with methanol: water: isopropanol: acetonitrile: sodium acetate (1 mM) 51:42:3:2:2: v/v/v/v/v/) with flow rate 1.7 ml/min and UV detection at 333 nm. The method is applied for the analysis of Isoniazid B.P Rambuzid and Myrene-p tablets. 1998-07-07T00:00:00Z http://localhost:80/xmlui/handle/123456789/16534 Title: COMPARATIVE ANALYSIS OF PULSED (ACTIVATED) AND RESTING CHICKEN CYTOCHROME C OXIDASES WITH SODIUM CHLORIDE DEPENDENCE OF THE ENZYME Authors: MUHAMMAD NISAR ALIZAI; WILSON, M.T.; NISAR MUHAMMAD NISAR Abstract: Comparative investigation of pulsed (activated) chicken cytochrom c oxidase and resting enzyme are compared with other species and pH dependent properties are also monitored Sodium chloride dependence of chicken oxidase is analysed and compared with that of beef cytochrome c oxidase. Carbon monoxides binding and spectral changes during this process is also discussed. S values are also determined at different pH of the enzyme ultra centrifugation. 1998-07-06T00:00:00Z http://localhost:80/xmlui/handle/123456789/16533 Title: RESISTANCE PATTERN OF CLINICAL ISOLATES FROM CASES OF CHRONIC EAR INFECTION II Authors: ADAM ALI; S. BAQAR SHYUM NAQVI; DILNAWAZ SHEIKH Abstract: During present study hundred clinical isolates from cases of ear infection were tested from local population for resistance pattern, using eleven different antibiotics. A considerable percentage of isolates causing ear infection was resistant to number of antimicrobial drugs. The percentages of organisms isolated from ear infection are Pseudomonc&c aeruginasa (50%), Proteus species (16%), Staphylococcus aureus (15%), Klebsiella species (13%) and Escherichia coli (6%). 1998-07-05T00:00:00Z