http://localhost:80/xmlui/handle/123456789/16539 2026-04-16T09:05:42Z http://localhost:80/xmlui/handle/123456789/16625 Title: DNA repair, cancer and gene therapy Authors: S A Rasool; R Ali; A Mirza; T Yasmeen; R Mushtaque Abstract: Fidelity of DNA synthesis is pivotal to our understanding of fundamental biological processes. An organism must replicate and repair its DNA with high accuracy and precision in order to maintain its genetic activity. DNA repair pathways enable cells to offer enhanced resistance to deleterious effects of chemicals and radiations (Lindahl, 1982). A number of pathways have been described e.g. the error-prone SOS repair (that lacks fidelity of repair process),the error-proof adaptive repair of alkylated DNA and inducible response to oxygen radical damage in DNA. These different circuits are under positive regulatory controls. However, the biochemical strategies employed to generate specific protein activators differ among the pathways. Although, the universally occurring repair activities seem to serve efficiently to counteract malignancy, error-prone polymerase and plasminogen activator have been instrumental in tumorigenesis, the process that proceeds by cascading of genetic errors (Sancar and Sancar, 1988). 1992-07-11T00:00:00Z http://localhost:80/xmlui/handle/123456789/16624 Title: Biochemical and electrophoretical studies of the effect of some chemosterilants on theenzymes of aedes aegypti (L.) larvae Authors: S N Naqvi; H M Sulaiman; A M Mohammad; M Afzal Abstract: In vivo effect of standard and prospective chemosterilants on some enzymes is reported. Colorimetric and histochemical findings indicate that alkaline phosphatase is inhibited by shikonin, hempa, tepa and shikonin angelate. Cholinesterase is inhibited by all the compounds while diphenol oxidase is not inhibited. These findings have been discussed in the light of the earlier observations. 1992-07-10T00:00:00Z http://localhost:80/xmlui/handle/123456789/16623 Title: Determination of toxicity of danitol, methoprene and neem formulation against stored grain pest, sitophilus oryzae L Authors: R Tabassum; M Jahan; M A Azmi; S N Naqvi Abstract: Toxicity of a synthetic pyrethroid (Danitol 10 E.C.), methoprene (J.H.A.) and crude neem extract formulation (RB-b +PBO +Tx) in synergestic form was determined in laboratory by contact method against adults of Sitophilus oryzae. Observations after 24 hours of treatment showed that 50% of the adults died at 0.39 mu/cm(2) of Danitol, 6.28 mug/cm(2) of neem formulation and 18.85 mug/cm(2) of methoprene, the three products used in this experiment. Danitol was found more effective as compared to neem formulation and methoprene. It was found that the plant product formulation and a synthetic product are more effective than methoprene. 1992-07-09T00:00:00Z http://localhost:80/xmlui/handle/123456789/16622 Title: In vitro antibacterial studies of some newly synthesized phenacyl-thiosemicarbazones Authors: S M Khalid; S A Khan; M Arif; S Shafiq; Z S Saifi Abstract: Four different phenacyl-thiosemicarbazone compounds were studied for their antibacterial activity against seventeen different species/strains. Of the four compounds under study, O-methoxy- phenacyl-thiosemicarbazone was found to be highly active against almost all the cultures under study. The other compounds were also found to possess antibacterial spectrum, but in very high concentrations for some of the cultures. 1992-07-08T00:00:00Z