http://localhost:80/xmlui/handle/123456789/14252 Wed, 22 Apr 2026 22:33:18 GMT 2026-04-22T22:33:18Z http://localhost:80/xmlui/handle/123456789/16145 Title: REVIEW TRPC signaling mechanisms and therapeutic opportunities: Trapdoors are monitored by gatekeepers Authors: Ammad Ahmad Farooqi; Asma M Riaz; Shahzad Bhatti Abstract: This Review summarizes our current state of knowledge of the functional role of TRPC channels in health and disease, with particular emphasis on current advancements in the field. Additionally, this review provides an up-to-date summary of SKF-96365 acting on TRPC channels, and discusses strategies to further investigate the potential of these channels for therapeutic intervention. Wed, 31 Jul 2013 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/16145 2013-07-31T00:00:00Z http://localhost:80/xmlui/handle/123456789/16144 Title: Review on the demographic and social impact of methadonemedication therapy on Malaysian patients Authors: Mohamed Mansor Manan; Salmiah Mohd Ali; Khan, Muhammad Anwar Nawab; Sara Jafarian; Mohammed Abdul Hameed Abstract: This study is an observational cross-sectional study aimed to examine the possible demographic and social characteristics of patients enrolled at the Methadone Maintenance Therapy Adherence Clinic (MMTAC) in Malaysia. Medical records from year 2009 – 2011 were reviewed. Demographic, social characteristics and laboratory examinations such as age, gender, race, clinic attendances and urine analysis were recorded. Subjects were selected by means of convenient sampling but based on the specified inclusion and exclusion criteria. Data were analyzed by either Chi-square test, Fisher’s exact test Mann-Whitney U-test, with the limit of significance was set at p ≤ 0.05. Demographically, this study found that the ratio of Malays, Chinese and Indian enrolled to the MMTAC program is similar to the distribution of races in Malaysia. Their starting age for drug use was between 14-35 years and the age to enrolment between 30-58 years. Socially, many are unemployed, lowly educated and married. Most are drug users with a high percentage of HCV accompanied with impaired liver function. Retention rate was 87% but illicit drug use was at 57.50%. However, percentage of employment increased significantly after therapy. The study managed to identify several demographical and social distributions of patients attending the MMTAC. Although attendance rate was high, many were on illicit drug use. Nevertheless, employment rate improved significantly. Tue, 30 Jul 2013 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/16144 2013-07-30T00:00:00Z http://localhost:80/xmlui/handle/123456789/16143 Title: REVIEW Making personalized prostate cancer medicine a reality: Challenges and opportunities in the re-establishment of gold standards Authors: Ammad Ahmad Farooqi; Ghazala Butt; Gohar Yousaf; Muhammad Imran Qadir; Uzma Shaukat; Qaisar Mansoor; Madeeha Awan; Shahzad Bhatti; Almas Begum Abstract: Prostate cancer is a serious multidimensional disorder that arises because of misrepresentation of signaling cascades and acquired resistance against apoptosis. It is progressively becoming more insurmountable because of rheostat like switching of oncogenic signaling in androgen dependent and androgen depleted microenvironment. Additionally, oncogenic fusion proteins have been explored in prostate cancer tissues thus adding another layer of complexity to the targeting of protein network in cancer cell and generate hurdles in the standardization of therapy. In this review we briefly describe identified oncogenic fusion transcripts in prostate cancer and suggest utilization of this biomarker for prostate cancer diagnosis alongwith standard PSA and immunohistochemistry analysis in Pakistan. We also provide overview of animal model studies to interpret the efficacy of vitamins. Mon, 29 Jul 2013 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/16143 2013-07-29T00:00:00Z http://localhost:80/xmlui/handle/123456789/16142 Title: REPORT Antibacterial activity of local herbs collected from Murree (Pakistan) against multi-drug resistant Klebsiella pneumonae, E. coli and methyciline resistant Staphylococcus aureus Authors: Qaisar Mansoor; Saira Shaheen; Uzma Javed; Uzma Shaheen; Irum Iqrar; Muhammad Ismail Abstract: Exploring healing power in plants emerged in prehistory of human civilization. Sustaining good health has been achieved over the millions of years by use of plant products in various traditional sockets. A major contribution of medicinal plants to health care systems is their limitless possession of bioactive components that stimulate explicit physiological actions. Luckily Pakistan is blessed with huge reservoir of plants with medicinal potential and some of them; we focused in this study for their medicinal importance.In this study we checked the antibacterial activity inherent in Ricinus communis, Solanum nigrum, Dodonaea viscose and Berberis lyceum extracts for multidrug resistance bacterial strains Klebsiella pneumonae, E. coli and methyciline resistant Staphylococcus aureus. MRSA showed sensitivity for Ricinus communis. Multidrug resistant Klebsiella pneumonae was sensitive with Pine roxburgii and Ricinus communis but weakly susceptible for Solanum nigrum. Multidrug resistant E. coli was resistant to all plant extracts. Treatment of severe infections caused by the bacterial strains used in this study with Ricinus communis, Pine roxburgii and Solanum nigrum can lower the undesired side effects of synthetic medicine and also reduce the economic burden. Sun, 28 Jul 2013 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/16142 2013-07-28T00:00:00Z