http://localhost:80/xmlui/handle/123456789/14326 Thu, 23 Apr 2026 14:12:51 GMT 2026-04-23T14:12:51Z http://localhost:80/xmlui/handle/123456789/16207 Title: A mini-review of therapeutic potential of Mangifera indica L. Authors: Nazima Batool; Noshin Ilyas; Sumera Shabir; Maimoona Saeed; Roomina Mazhar; Amjid, Muhammad Waqas Abstract: Among known species of 69 Mangifera, Mangifera indica L. is a medicinal plant being used in tropical regions by indigenous people. It has been a main plant species being used in Ayurvedic as well as indigenous medical systems form 4000 years. Components of M. indica are recurrently used as a traditional medicine system to cure numerous ailments. Active constituents are present in stem bark, leaves, heartwood, roots and fruit and have antioxidant, anti-inflammatory, radioprotective, antitumor, immune-modulatory, anti-allergic, anti-diabetic, anti-bone resorption, mono-amine oxidase inhibiting, anti-viral, anti-fungal, anti-bacterial, anti-spasmodic, antidiarrheal, anti-malarial, antiparasitic as well as lipolytic properties. In spite of essential progress in phyto-chemical and medicinal analysis of M. indica, more efforts are needed to explore M. indica active components and their application in pharmaceutical industry. In this review, we focus on recent information about chemical constituents and pharmacological uses of M. indica. Fri, 20 Jul 2018 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/16207 2018-07-20T00:00:00Z http://localhost:80/xmlui/handle/123456789/16204 Title: Immunological study of different fraction of wheat proteins Authors: Shaista Khan; Khaskheli, Muhammad Hassan; Ghulam Nabi; Deverajani, Bikha Ram; Naima Memon; Shar, Ghulam Abbas Abstract: Wheat allergy specifically refers to the adverse reaction involving IgE antibody to one or more protein fraction of wheat such as albumin, globulin, gliadin and glutenin (gluten). The majority of IgE-mediated reactions to wheat involve albumin and globulin fraction while gluten (gliadin & glutenin) also cause allergy (Celiac disease). Allergic reactions to wheat may be caused by ingestion of wheat containing foods or inhalation of flour (Bakers asthma). The present study was an effort to explore the antibody response of different proteins present in wheat. ELISA results revealed that the antibody response for albumin varied from 0.92-1.78, whereas, for globulin ranged from 1.39-1.60. Antibody response against glutenin and gliadin ranged from 0.57-1.05 and 0.98-1.95 respectively, among the different varieties of wheat. All the tested wheat varieties showed the significant difference antibody response against the different fractions of protein. Fri, 20 Jul 2018 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/16204 2018-07-20T00:00:00Z http://localhost:80/xmlui/handle/123456789/16200 Title: Role of prostaglandin H synthase in activation of acrylonitrile to cyanide Authors: Abbasi-Al, Ahmed Fahad; Esmat Ahmed; Mohamadin, Mohamed Ahmed; Abdel Naim, Ashraf Bahyeldeen Abstract: The present study aimed at investigating the in-vitro oxidation of acrylonitrile (ACN) to cyanide (CN−) by prostaglandin H synthase (PHS). Detection of CN− is considered a marker for free radical intermediates involved in ACN-induced toxicity. First, most favorable circumstances for ACN oxidation were characterized: pH (4.5), temperature (37ºC) and time of incubation (60 min.). In addition, the concentrations of ACN, PHS and H2O2 in incubation mixtures were assessed for further reaction characterization. The reaction maximum velocity (Vmax) was calculated to be 582.75 pmol CN−/mL/min and the Michaelis-Menten constant (Km) was 149.25 µmol ACN. Adding PHS inhibitors; resveratrol, quercetin, indomethacin or troloc-C to the reaction mixtures significantly reduced the rate of ACN oxidation. In conclusion, the present study demonstrates the ability of PHS to oxidize ACN to CN− and provides a clue for the explanation of ACN target toxicity. Fri, 20 Jul 2018 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/16200 2018-07-20T00:00:00Z http://localhost:80/xmlui/handle/123456789/16199 Title: Antioxidant, cytotoxicity, protein kinase inhibition and antibacterial activities of Fragaria × ananassa leaves Authors: Ihsan Khan; Saira Tabassum; Tofeeq-ur-Rehman; Muhammad Ikram; Ihsan ul Haq; Muhammad Zia Abstract: Fragaria × ananassa leaves extracts prepared in different solvents were subject for antioxidative, cytotoxicity, protein kinase inhibition and antibacterial activities. The extracts showed varying activities depending upon solvent used for extraction. Combined effect of methanol and ethyl acetate showed maximum antioxidant and reducing power potential (207.65±6µg AAE/mg and 88.58±20µg AAE/mg, respectively). Maximum DPPH (2,2-diphenyl-1-picryl hydrazyl) free radical scavenging activity was calculated by when methanol: chloroform and acetate fractions were used (87.68% and 86.88% inhibition, respectively). Total phenolics varied from 186 to 1.91µg AAE/mg while total flavonoids also significantly varied among the extracts. The extracts also showed significant activities against brine shrimp larvae and bacterial strains tested. The study concludes that Fragaria × ananassa leaves can be a good source for isolation of active phytochemicals to be used in different industries. Fri, 20 Jul 2018 00:00:00 GMT http://localhost:80/xmlui/handle/123456789/16199 2018-07-20T00:00:00Z