DSpace Collection:

Clinical observation of minocycline hydrochloride ointment in the treatment of early peri-implantitis

Fri, 20 Sep 2019 00:00:00 GMT

Title: Clinical observation of minocycline hydrochloride ointment in the treatment of early peri-implantitis Authors: Tian, Bao Abstract: To observe and analyze the therapeutic efficacy of minocycline hydrochloride ointment in the treatment of early peri-implantitis. A total of 180 patients with early peri-implantitis and treated at our hospital were enrolled. The patients were divided into control group and research group, with 90 patients in each group. Of those, patients in the research group were treated with minocycline hydrochloride ointment, while 10% of iodine was placed around the teeth in patients of the control group. The therapeutic efficacy was observed and compared between both groups. By comparing the plaque index of both groups after treatment, results showed that the improvement of the research group was obviously better than that of the control group (p<0.05). By comparing the probing depth and sulcus bleeding index, results showed that the situation of the research group was significantly superior than that of the control group (p<0.05). Application of minocycline hydrochloride ointment in the treatment of early peri-implantitis could significantly improve the therapeutic efficacy.

Evaluation of prokinetic and laxative effects of Hippophae rhamnoides in rodents

Fri, 20 Sep 2019 00:00:00 GMT

Title: Evaluation of prokinetic and laxative effects of Hippophae rhamnoides in rodents Authors: Hanif, Muhammad; Mehmood, Malik Hassan; Ishrat, Ghazala; Abdullah, Ahmed; Sohail, Samar; Ahmed, Mansoor; Gilani, Anwarul-Hassan Abstract: Hippophae rhamnoides (Family; Elaeagnaceae) fruit extract was investigated for prokinetic and gut excitatory effects to rationalize its therapeutic utility in gastrointestinal complaints like delayed gastric emptying and constipation. The fruit extract of Hippophae rhamnoides (Hr.Cr) prepared in hydro-methanol (30:70) was verified for flavonoids, tannins, coumarins and terpenes as plant constituents. In mice, Hr.Cr administration caused an increased in faecal production and charcoal meal transport (50-300mg/kg, per-oral.), similar to activity pattern of carbamylcholine (1 mg/kg). Laxative and prokinetic effects of Hr.Cr were found partially atropine-sensitive. On challenge with isolated intestinal tissues, Hr.Cr charged a dose-dependent spasmogenic effect on jejunum (0.01-1mg/mL) preparations of rabbit and in ileal tissues (guinea-pig) at the dose range of 0.03 to 3mg/mL, following predominant relaxing impact at increased concentrations. Unlike carbamylcholine, stimulant effect of Hr.Cr was partly antagonized in atropine incubated tissues. These data attest the laxative, prokinetic and gut excitatory activities of Hippophae rhamnoides probably mediated through partial activation of muscarinic receptors. Further in agreement of the current findings with earlier reports on gastric emptying effects of Hippophae rhamnoides seed oil, this is the first study of its kind providing insight into mechanism to the laxative potential of Hippophae rhamnoides fruit, thus rationalizing its medicinal use in constipation.

Antifungal and anti-aflatoxin efficacy of biogenic silver nanoparticles produced by Aspergillus species: Molecular study

Fri, 20 Sep 2019 00:00:00 GMT

Title: Antifungal and anti-aflatoxin efficacy of biogenic silver nanoparticles produced by Aspergillus species: Molecular study Authors: Ibrahim Al-Zaban, Mayasar; Shazli, Nahla; Azim, Abdel; Ramadan Mohamed, Abeer; Abd El-Aziz, Mohamed Abstract: Date palm (Phoenix dactylifera L.) is considered the main crop in deserts and arid areas such as Saudi Arabia. Fifteen species belonging to 7 fungal genera were isolated from date palm rhizosphere soil at Riyadh, Saudi Arabia. Twenty-one isolates of Aspergillus spp. were used in producing silver nanoparticles (SNPs), five of A. flavus, nine of A. niger and seven of A. terreus. Synthesis of SNPs by these fungi is emerging as an important branch of nanotechnology due to it’secofriendly, safe and cost-effective nature. SNPs have been characterized by UV-Visible Spectrophotometer and Transmission Electron Microscope (TEM). In order to increase the yield of biosynthesized SNPs of desired shape and size, it is necessary to control the cultural and physical parameters during the synthesis. We reported the optimum synthesis of SNPs on a liquid medium at 1.5mM of silver nitrate, pH 9 and 26°C after 96 hours. Antifungal activity of SNPs colloids has indicated that the highest inhibition zone was detected with SNPs. In the case of SNPs synthesized by A. terreus PNU37, the highest Inhibition percentage (IP %) 67.6% at the concentration 150 ppm of SNPs. Results have also indicated that the SNPs synthesized by A. flavus PNU05 at a concentration of 150 ppm/100 ml culture medium gave the highest reduction of B1 determined by HPLC, where the percentages of reduction (PR%) was 56.45%.ISSR analysis revealed a high level of genetic diversity in the Aspergillus spp. population and useful for genetic characterization. ISSR markers were not suitable to discriminate between producing and non-producing SNPs isolates. There was no clear-cut relationship between the ISSR markers (genotype of isolates), antifungal and anti-aflatoxigenic properties.

Impact of formulation variables on weight uniformity of scored tablets using factorial design

Fri, 20 Sep 2019 00:00:00 GMT

Title: Impact of formulation variables on weight uniformity of scored tablets using factorial design Authors: Zaid, Abdel Naser; Hawari, Raghda; Malkieh, Numan; Natshih, Yasmin; Yousef, Abeer; Jaradat, Nidal; Hammad, Aysha; Basharat, Rebhi Abstract: Maintaining safety and efficacy is an important task when splitting a tablet. This Pharmacy practice affords the patient with unavailable required dose, easy swallowing, and cost-saving measure. To access the role of formulation variables on the weight uniformity test of halves tablets. Uncoated and coated placebo tablets were prepared using wet granulation technique. After compression, hardness, disintegration time, friability and weight variation were evaluated according to the USP test. Both coated and uncoated tablets were dived and the obtained halves were weighed and the uniformity of halves was assessed for each kind of tablets. Despite the hardness, size, tablet shape (oval, disc, capsule), all of them passed the splitting test except for the disc shape which showed %RSD higher than 6%. However, hardness and the coating had a generally positive trend on tablet breaking since they gave low% RSD. These findings suggest that the disc shape particle is not suitable for breaking. In addition, film coating, as well as high hardness may give better uniformity of the obtained halves, since a decrease in the calculated %RSD was observed.