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A STUDY ON THE EFFECTS OF SOME NEW DERIVATIVES OF PIPERIDINE ON NEUROTRANSMITTERS

Thu, 07 Jan 1999 00:00:00 GMT

Title: A STUDY ON THE EFFECTS OF SOME NEW DERIVATIVES OF PIPERIDINE ON NEUROTRANSMITTERS Authors: Z.S. SAIFY; HANIFA SHAHNAZ; SHAMIM AKHTAR; MOAZZAM HAIDER; DARAKHSHAN JABEEN HALEEM Abstract: Four chemically synthesized derivatives of piperidine were subjected to evaluate their pharmacological actions on Nervous System in male albino mice. The effects on neurotransmitters such as catechol amine and indolamine assuming that these derivatives might alter them differently, studied by HPLC-EC method. The result revealed that brain dopamine and catecholaminc were altered by most of these derivatives at the doses of 100mg/kg body weight.

SWELLING BEHAVIOUR OF pH-SENSITIVE CROSSLINKED POLY(VINYL ACETATE CO-ACRYLIC ACID) HYDROGELS FOR SITE SPECIFIC DRUG DELIVERY

Wed, 06 Jan 1999 00:00:00 GMT

Title: SWELLING BEHAVIOUR OF pH-SENSITIVE CROSSLINKED POLY(VINYL ACETATE CO-ACRYLIC ACID) HYDROGELS FOR SITE SPECIFIC DRUG DELIVERY Authors: N.M. RANJHA Abstract: The present work was undertaken to combine nonionic vinyl acetate (VAC) with anionic acrylic acid (AA) or methacrylic acid (MAA) monomers in the presence of ethylen glycol dimethacrylate (EGDMA) as crosslinking agent through radical polymerization. Poly (vinyl acetate-co-acrylic acid) VAC/AA 50:50 to 100:0 six samples and Poly(vinvl acetatecomethacrylic acid) VAC/MAA one sample were prepared. All the samples were used for swelling studies. High swelling occurred at above pH 5.5 through chain relaxation. It was observed that swelling to VAC/MAA was lower than VAC/AA copolymers. The lower swelling in VAC/MAA copolymer is due to the presence of hydrophobic methyl group and higher pKa value of this copolymer.

PHARMACOKINETIC STUDY ABOUT INTERACTION OF NAPROXEN AND ISONIAZID

Tue, 05 Jan 1999 00:00:00 GMT

Title: PHARMACOKINETIC STUDY ABOUT INTERACTION OF NAPROXEN AND ISONIAZID Authors: MUHAMMAD TAYYAB ANSARI; BASHIR AHMED LOOTHAR; KHAN, QASIM JAHANGIR Abstract: Effect of Naproxen (500 mg) was studied on the pharmacokinetic characteristics of Isoniazed (300 mg) in ten healthy human volunteers in a complete cross-over design. A high performance liquid chromatography (HPLC) method was used to analyze serum drug concentrations. Naproxen caused a highly significant (P<0.001) increase in AUC, significant (P<0.05) increase in elimination half life (t1/2) and time for the maximum drug concentration (tmax) while significant (P<0.05) decrease in elimination rate constant (Ke). Insignificant decrease and increase was observed in absorption rate constant (Ka) and maximum drug concentration (Cmax) respectively.

INCREASED PRECURSOR AVAILABILITY DID NOT INCREASE FOOD INTAKE AND 5-HT TURNOVER RATE IN THE HYPOTHALAMUS OF DIAZEPAM INJECTED RATS

Mon, 04 Jan 1999 00:00:00 GMT

Title: INCREASED PRECURSOR AVAILABILITY DID NOT INCREASE FOOD INTAKE AND 5-HT TURNOVER RATE IN THE HYPOTHALAMUS OF DIAZEPAM INJECTED RATS Authors: FARHAT BATOOL; DARAKHSHAN JABEEN HALEEM Abstract: In view of a possible role of serotonin (5-hydroxytryplamine 5-HT) in regulation of appetite and anxiety, the effects of 1,3 and 5mg/kg doses of diazepam on brain serotonin precursor and effects of single and repeated diazepam (1 mg/kg 2* daily for 4 days) administration on hypothalamic 5-HT, 5- hydroxyindoleacetic acid (5-HIAA and 5-HIAA/5-HT ratio are investigated in rats. Daily diazepam treatment decreased food intakes. Diazepain injected rats exhibited a dose-dependent increase of tryptophan in the hypothalamus. Administration of diazepam (1 mg/kg) to 4 day saline injected rats on the 5th day in-creased 5-HT and decreased 5-HIAA levels in the hypothalamus. 5- HIAA/5-HT level also decreased. 4 day diazepam injected rats injected with saline on the 5th day also ex hibited similar changes of 5-HT. 5-HIAA and 5- HIAA/5-HT ratio. Administration of diazepam to 4 day diazepam injected rats again decreased 5-HIAA concentrations but did not in-crease 5-HT levels in the hypothalami of rats. Possible mechanism involved in the anorectic effects of diazepam-induced changes of hypothalamic 5-HT turnover rate is discussed.