Synthesis, Characterization and Applications of Novel Derivatives of Organoflourines and their Metal Complexes

Abstract

3- tri fluoro methyl aniline and 2-fluoro aniline are used to synthesize a series of Schiff bases and their metal complexes. These fluoro substituted anilines were reacted with salicylaldehyde, 5-bromo salicyldehyde, 3,5 di bromo salicyldehyde, ortho vanillin and 2 hydroxy naphthaldehyde to get fluoro substituted imines. Using these fluoro imines as ligands, their transition metal complexes were synthesized for which copper (II), nickel (II) and zinc (II) were selected for complex formation. Characterization of all of these synthesized compounds was done using UV-Vis spectrophotometry, FT-IR, Proton NMR, Carbon NMR and single crystal XRD. The Metal to Ligand ratio in the synthesized metal complexes were estimated using AAS (Atomic Absorption Spectroscopy). Various biological applications of these synthesized compounds were studied. All of these Organofluorines Ligands and their metal complexes showed good antibacterial activity against various strains of bacteria. Antifungal, anti-cancer and anti-inflammatory activities of these imines and their metal complexes were also studied. The results showed that these compounds have a potential to be used as antifungal and anti-inflammatory agents however poor anticancer activity was showed by these compounds.