Synthesis of biologically active organotin compounds containing germanium and silicon

Abstract

Four different series of some new di-and triorganotin and organogermanium carboxylates have ‎been prepared. Of them eight compounds of general formula ‎‎(R1(CH3)2SiCH2)2Sn(O2CCH2(R2)CHGeR33)2 where R1=CH3, C2H5; R2=C6H5, C6H4OMe3/4; ‎R3=CH3, N(CH2CH2O)3 have been synthesized from (R1(CH3)2SiCH2)2SnCL2 AND ‎R33GeCH(R2)CH2CO2H in the presence of triethylamine. Second series of new triorganotin ‎carboxylates containing germanium with general formula R1GeCHR2CH2COO)Sn(CH2C(CH3)3)3 where R1=N(CH2CH2O)3, C6H5; R2=C6H5, p-C6H4OCH3 ‎and o-/p-C6H4F were synthesized.‎ Another series of diorganotin(IV) derivatives of general formula (R3'GeCHRCH2COO)2SnR2'' ‎have been prepared by the reaction of diorganotin chlorides/oxides with substituted germyl ‎propionic acids. A series of ten new organogermanium compounds with general formulae ‎C21H16RGeN2O4 and C13H12RGeNO3 have also been prepared from GeO2 by hydrogermanation ‎reaction in the presence of different substituted 3-trichlorogermyl propionic acids. Thus ‎prepared substituted acids were complexed with 8-quinolinol and 2-methyl-8-quinolinol.‎ All above compounds have been characterized by various analytical techniques such as ‎elemental analysis, IR, multinuclear NMR (1H, 13C, 119Sn) and mass spectrometry. Some selected ‎compounds have also been subjected to Mossbauer spectroscopy. The single crystal structures ‎of precursors like Ph3GeCHRFCH2COOH (RF = 4-FC6H4) and (p-‎CH3C6H4)3GeCH(Ph)CH(Me)COOH has been determined by X-ray diffraction. Biological ‎studies like cytotoxicity, antibacterial, antifungal enzyme-inhibition and antileishmanial activity ‎have shown their potential in the treatment of leishmaniases and ulcers.‎

All above data has been tabulated in the form of four research papers complete in all respects ‎either accepted in foreign journal or submitted for publication.‎