BIOCHEMICAL STUDIES ON TRAUMA

Abstract

A Total of 214 head trauma, 33 abdominal trauma and 28 normal healthy subjects were studied. Most of the trauma patients were male and highest number of these patients suffered from motorcycle accidents. Inpact was severe in most of the grade IV patients and large number of them were deeply comatose. Biochemical studies were conducted on blood, urine and cerebrospinal fluid. Alteration in CSF sugar, urea magnesium and inorganic phosphorus were abserved. There was destinet hyperglycemia in acute phase of 1-3 days followed by recovery to normal or near normal values. Discrepancies in blood lactate, pyruvate, serum cortisol were also abserved for all the three days. Blood ATP was increased in all the trauma patients with a decrease in ADP and AMP. Serum total proteen, albumin, globulin, A/G ratio and urea concentration were also varied from the controls. Serum sodium, postassium and magnessium were also found to be elevated with a decrease in calcium and inorganic phosphorus. No change was observed in serum alkaline phosphatase in all the trauma patients. In few instances mostly in grade IV head injury patients serum amylase was elevated on just two days of trauma. Urinary retention of sodium, potassium, inorganic phosphorus, magnesium, calcium and urea were abseryed for all the three days with a decrease in urinary volumes. Most of grade III and IV patients suffered from moderate type of scalp injury and if fracture was present it was mostly present in the frontal bone.