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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/12794
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dc.contributor.authorQasim, Muhammad-
dc.contributor.authorBukhari, Shazia Anwer-
dc.contributor.authorGhani, Madiha Javeed-
dc.contributor.authorMasoud, Muhammad Shareef-
dc.contributor.authorHuma, Tayyabah-
dc.contributor.authorArshad, Muhammad-
dc.contributor.authorHaque, Asma-
dc.contributor.authorIbrahim, Zubair-
dc.contributor.authorJaved, Sadia-
dc.contributor.authorRajoka, Muhammad Ibrahim-
dc.date.accessioned2022-10-07T10:39:05Z-
dc.date.available2022-10-07T10:39:05Z-
dc.date.issued2016-11-16-
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/12794-
dc.description.abstractAmounts of DNA damage and homocysteine (Hcy) in heart patients blood may have strong function in the causation of cardiovascular disease (CVD). The main objective of this work was to know experimentally the role of total oxidants (produced by Reactive Oxygen species (ROS), clinical biochemical indices, their oxidized products and total antioxidant status (TAS) among such patients to find the association of homocysteine, total oxidation status (TOS) and oxidative DNA damage with other clinical parameters in sixty positive CVD patients compared with those of 60 normal subjects. As compared to healthy individuals, CVD patients had significantly higher concentrations of homocysteine (p<0.0001), total oxidants stress (TOS) (p<0.0001), serum total lipids (p<0.04), malondialdehyde (MDA) (p<0.001), high density lipoprotein-cholesterol (HDL-C) (p<0.0001), and low density lipoprotein cholesterol (LDL-C) (p<0.01), than those of healthy individuals. Plasma Hcy content, TOS and amount of DNA were positively and significantly associated with cholesterol, triglycerides, systolic blood pressure, urea, and albumin (p values<0.01). TOS, Hcy and oxidative DNA damage were negatively correlated with HDL-c, TAS and proteins. It is suggested that these parameters have pivotal role in diagnostic process of determining severity in CAD patients. Oxidized products of macromolecules in blood of CVD patients impart major functions in causing CVD disease.en_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachien_US
dc.subjectAntioxidantsen_US
dc.subjectheart diseaseen_US
dc.subjectCVDen_US
dc.subjecthomocysteineen_US
dc.subjectTOSen_US
dc.subjectDNA damageen_US
dc.subjectmalondialdehydeen_US
dc.subject8-Hydroxy2’deoxyguanosineen_US
dc.titleRelationship of oxidative stress with elevated level of DNA damage and homocysteine in cardiovascular disease patientsen_US
dc.typeArticleen_US
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