Need of statins among un-diagnosed unaware Pakistanis via revised pool cohort equation by American Heart Association

Abstract

National diseases burden of cardiovascular diseases is the top leading cause of death in Pakistan. In this study, Pakistani has been assessed for Atherosclerotic Cardiovascular Disease (ASCVD) on the basis of American Herat Association (AHA) guidelines. The aim of the study is to assess and inform about 10-year risk and life time risk in people residing in the largest metropolis city Karachi and aware about the use of statins as per revised Pooled Cohort Equation guidelines. The study sample size was 1760 with the age of 39 to >80 years with non-atherosclerotic diseases.Both genders without language barrier with or without elevated lipid were included. Clinical investigations including HDL, B.P and serum TG were included for calculating the ten year and life time risks on the basis of <5%, 5-7% and >7.5%. Results shows that the Odd ratio >1 found between age and TC however significant relationship (p<0.05) between gender, diabetes, hypertension and smokers were established. >50% study population required moderate and high intensity statin however <30% needed life style modification for reducing cardiac on risk. It is concluded that current recommendations are not for South Asians and may under or overlook the risks of individuals living in this continent. This study estimates the cardiovascular risk burden in the population of Karachi, Pakistan who were nonatherosclerotic undiagnosed and un-treated. This risk assessment may modify the algorithm and successfully identify the risk burden in present study groups.