Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/12823
Title: Chicory (Cichorium intybus L.) extract ameliorates hydroxyapatite nanoparticles induced kidney damage in rats
Authors: A El-Masry, Thanaa
Altwaijry, Najla
Alotaibi, Badriyah
Tousson, Ehab
A, Alboghdadly
Saleh, Asmaa
Keywords: Hydroxyapatite nanoparticles (HAP NPs)
Chicory extract, kidney, Bax
PCNA and TNFα expressions
Issue Date: 5-May-2020
Publisher: Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.
Citation: El-Masry, T., Altwaijry, N., Alotaibi, B., Tousson, E., Alboghdadly, A., & Saleh, A. (2020). Chicory (Cichorium intybus L.) extract ameliorates hydroxyapatite nanoparticles induced kidney damage in rats. Pak. J. Pharm. Sci, 33(3), 1251-60.
Abstract: Hydroxyapatite nanoparticles (HAP NPs) are a calcium phosphate, basically and artificially like the mineral period of human bone and teeth. Current study were performed to study the therapeutic effects of chicory extract towards the injection of hydroxyapatite nanoparticles (HAP NPs) in rat induced kidney damage by decreasing kidney functions, electrolytes, cytokines and apoptosis. An aggregate of 40 Wistar male rats were divided into 4 equal groups [control, chicory, HAP NPs, treated HAP NPs with chicory (HAP NPs+chicory)]. Rat treated with HAP NPs exhibit increased serum creatinine, urea, cystatin C, potassium ions, chloride ions, kidney injury, Bax, PCNA and TNFα expression. In contrast; decline in serum sodium and calcium ions. Post treatments of HAP NPs with chicory extract (HAP NPs+chicory) improved the kidney structure and functions. We can conclude that; chicory extract may offer advantages against the dangerous nature of hydroxyapatite nanoparticles (HAP NPs).
URI: http://142.54.178.187:9060/xmlui/handle/123456789/12823
ISSN: 1011-601X
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