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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/12990
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dc.contributor.authorAhmad Khan, Kamran-
dc.contributor.authorMajid Khan, Gul-
dc.contributor.authorUllah Shah, Kifayat-
dc.contributor.authorRasul Niazi, Zahid-
dc.contributor.authorKhan, Haroon-
dc.contributor.authorAhmad, Ashfaq-
dc.contributor.authorur-Rehman, Fazal-
dc.contributor.authorAkhtar Shah, Pervaiz-
dc.contributor.authorUllah, Aziz-
dc.contributor.authorTahir, Muhammad-
dc.contributor.authorUmer Jan, Syed-
dc.date.accessioned2022-10-12T06:05:15Z-
dc.date.available2022-10-12T06:05:15Z-
dc.date.issued2020-09-03-
dc.identifier.citationKhan, K. A., Khan, G. M., Shah, K. U., Niazi, Z. R., Khan, H., Ahmad, A., ... & Jan, S. U. (2020). Design, Preparation and evaluation of various parameters of controlled release matrices of losartan potassium using polymers combination. Pakistan Journal of Pharmaceutical Sciences, 33.en_US
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/12990-
dc.description.abstractControlled release formulations are administered once a day and reduce frequency of dose and ensuring patient’s compliance. In the current research controlled release matrices of losartan potassium formulated with polymeric combinations of ethocel grade 7 with carbopol 934P NF using different concentrations of polymers. In some polymeric tablets, Co-excipients like CMC, Starch, HPMC was added by replacing of 10% of filler in formulations at 10:5. Tablets were prepared by direct compression method and evaluated for physicochemical characteristics. USP Method-1 (rotating basket method) was used to carry out dissolution study in phosphate buffer pH 6.8. Drug release kinetics determined and comparison of dissolution patterns was done with reference tablets. The polymeric combinations well retarded drug release and drug was released by anamolous non-fickian diffusion mechanism. Dissolution profiles of tested tablets and reference tablets were found not similar. Drug release rate was increased by co-excipients. It was concluded from this research work that this polymeric combination can be used efficiently in designing of controlled release martices.en_US
dc.language.isoenen_US
dc.publisherKarachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.en_US
dc.subjectControlled release formulationen_US
dc.subjectdissolutionen_US
dc.subjectcombinationen_US
dc.subjectLosartan Potassiumen_US
dc.titleDesign, Preparation and evaluation of various parameters of controlled release matrices of losartan potassium using polymers combinationen_US
dc.typeArticleen_US
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