Topical vs Combination Ofloxacin in the Management of Discharging Chronic Suppurative Otitis Media

Abstract

Aim: To assess the effectiveness of topical ofloxacin ear drops in comparison with combination of topical and oral ofloxacin as the first line management among patients with chronic suppurative otitis media. Methods: It was prospective randomized interventional clinical trial in which 50 patients with severe episode of chronic suppurative otitis median (CSOM) visiting outpatient department were included. Results: Among 100 patients, 60.0% were males and 40.0% were females. Pseudomonas aeruginosa was most prevalent organism isolated from forty five patients and Klebsiella from thirty patients. These all organisms were sensitive to Ciprofloxacin. Conclusion: During systemic infectivity absence or acute underlying disease, the topical antibiotics alone comprise first line therapy for most of the patients with CSOM, finding no confirmation that systemic antibiotics alone or in combination with topical preparations enhance treatment outcomes compared with topical antibiotics alone