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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/13023
Title: Hematological and toxicological effects of aqueous leaf extract of Stevia rebaudiana Bertoni in normal rat modals
Other Titles: Hematological and toxicological effects of aqueous leaf extract of Stevia rebaudiana Bertoni in normal rat modals
Authors: Ahmad, Uswa
Shabir Ahmad, Rabia
Shahbaz, Muhammad
Imran, Ali
Haseeb, Muhammad
Siddique, Farzana
Yasmin, Zarina
Ashraf, Ijaz
Masroor, Ashir
Basit, Abdul
Keywords: Stevia rebaudiana Berton
stevioside
hematology
toxicology
liver functioning enzymes
Issue Date: 6-Sep-2020
Publisher: Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.
Citation: Ahmad, U., Ahmad, R. S., Shahbaz, M., Imran, A., Haseeb, M., Siddique, F., ... & Basit, A. (2020). Hematological and toxicological effects of aqueous leaf extract of Stevia rebaudiana Bertoni in normal rat modals. Pakistan journal of pharmaceutical sciences, 33.
Abstract: Stevia rebaudiana Bertoni a non-caloric, safe and natural sweetener has been shown pharmaceutically important in the management of blood disorders. This study was designed to investigate hematology and safety of stevia aqueous extract through animal modeling. For this purpose, fifty albino rats were categorized into 5 groups and all the groups were received aqueous stevia extract at different dosage levels (200, 300, 400 and 500 ppm/kg b. wt) for 8 weeks except control group. Hematological and toxicological analyses were conducted using standard recommended procedures. The results indicated that biochemical parameters (RBC, HB, HCT, MCV, MCH, MCHC, WBC, eosinophils, lymphocytes and neutrophils) of albino rats significantly (P<0.05) increased and PLT, MPV and monocytes levels non-significantly decreased by using aqueous extract of stevia at different levels after eight weeks of study. Furthermore, Stevia aqueous extracts had non-toxic effect on liver functioning tests. However, stevia aqueous extracts were insignificant in their impression regarding organ to body weight ratios. The stevia aqueous extract has positive effect on hematological parameters of albino rats and is toxicologically safe. Therefore it could be used as a natural remedy for the management of hematological disorders without any health hazards.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/13023
ISSN: 1011-601X
Appears in Collections:Issue 5

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