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Title: | Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes |
Authors: | Islam, Nayyer Fawad Zahoor, Ameer Khalid Syed, Haroon Shahid Iqbal, Muhammad Ullah Khan, Ikram Abbas, Ghulam Mushtaq, Maria Ur Rehman, Mujeeb Rasul, Akhtar Ikram, Muzzamil Muhammad Ibrahim, Hafiz Inam, Sana Irfan, Muhammad |
Keywords: | Bilosomes ebastine phosphatidylcholine solubility drug release |
Issue Date: | 12-Sep-2020 |
Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
Citation: | Islam, N., Zahoor, A. F., Syed, H. K., Iqbal, M. S., Khan, I. U., Abbas, G., ... & Irfan, M. (2020). Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/bile salt bilosomes. Pakistan Journal of Pharmaceutical Sciences, 33. |
Abstract: | Although ebastine (EBT) can impede histamine-induced skin allergic reaction and persuade long acting selective H1 receptor antagonistic effects but its poor water solubility circumscribed its clinical application. The main objective of this research work was to improve the aqueous solubility and oral bioavailability of EBT by preparing EBTloaded bilosomes (EBT-PC-SDC-BS). A thin film hydration method was used to prepare ebastine loaded bilosomes. The prepared-formulations were optimized considering size, morphology and entrapment efficiency. The SEM images revealed regular and spherical shape of bilosomes. Average size of the prepared EBT-PC-SDC-BS was 665.8 nm and zeta potential was around-32.9 mV with 89.05 % average entrapment efficiency (EE).Importantly, the solubility of EBT in water was amplified up to 17.9 μg/ml compared to pure drug (2 μg/mL) reflecting a highest solubility increase of 751 %. In vitro drug release results of prepared EBT-PC-SDC-BS exhibited improved release behavior. Finally, it is established from the results that the EBT-PC-SDC-BS could function as a favorable nano-carrier system to improve the solubility as well as dissolution of EBT. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/13035 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 5 |
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12-SUP-1537.htm | 148 B | HTML | View/Open |
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