Hepatoprotective role of curcumin in rat liver cirrhosis

Abstract

The present research work was designed to evaluate the effects of biochemical parameters in rats with thioacetamide curcumin supplementation on various (TAA) induced liver cirrhosis. For this purpose 24 male Albino 200mg/kg Wistar rats were randomly distributed into four groups (n=6).Group I served as control, Group II and Group III received thioacetamide b.w , Group III received curcumin i.p , twice a week for 12 weeks in first phase. In second phase Group II received saline and 50mg/kg b.w /day, i.p b.w /day, i.p for 12 weeks, in second phase, Group IV received , for 12 weeks, in first phase and saline in second phase. Evaluation of curcumin histopathological 50mg/kg and biochemical parameters was carried out by liver histopathology and estimation of total and direct bilirubin, liver specific enzymes, antioxidant enzymes, MDA level, plasma and intraerythrocyte sodium and potassium respectively. Histopathology of liver showed highest degree of fibrosis and nodule formation, significant alteration in biochemical parameters indicated development of severe liver cirrhosis. Curcumin treatment showed reduced amount of fibrosis and significant reduction in level of liver biomarkers, reversal of antioxidant enzymes (SOD and GSH), MDA level, catalase activity and regain of electrolyte homeostasis. These findings confirm the protective role of curcumin in liver cirrhosis ..