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http://142.54.178.187:9060/xmlui/handle/123456789/13117| Title: | Antibacterial activity of usnic acid from Usnea longissima Ach. |
| Authors: | Maulidiyah, Maulidiyah Hadijah Sabarwati, Siti Harjuliarto, Rikhal Haris Watoni, Abdul Nurdin, Muhammad |
| Keywords: | Isolation Lichen Usnea longissima Ach antibacterial usnic acid |
| Issue Date: | 25-Jul-2020 |
| Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
| Citation: | Sabarwati, S. H., Harjuliarto, R., Watoni, A. H., & Nurdin, M. (2020). Antibacterial activity of usnic acid from Usnea longissima Ach. Pakistan Journal of Pharmaceutical Sciences, 33(4). |
| Abstract: | Isolation and identification of secondary metabolite from n-hexane fraction of lichen Usnea longissima Ach. and its bioactivity as antibacterial have been carried out. The isolation of chemical compounds was performed by using Gravity Column Chromatography (GCC), solvent systems as mobile phase (n-hexane, ethyl acetate), and Thin Layer Chromatography (TLC). The form of isolated compound was yellow needle crystals. The result of 1D-NMR (1H and 13CNMR) data showed that the isolated compound was usnic acid. Antibacterial bioactivity testing was conducted by using the paper disk diffusion method indicated that the usnic acid compound was actively inhibited the growth of E. coli (ATCC35218) and S. aureus (ATCC25923) at the concentrations of 500mg/mL and 1000mg/mL with inhibition zone between 12mm and 17mm. In addition, S. typhi (YCTC) was only inhibited at the concentration of 1000mg/mL with inhibition zone of 14mm. |
| URI: | http://142.54.178.187:9060/xmlui/handle/123456789/13117 |
| ISSN: | 1011-601X |
| Appears in Collections: | Issue 4 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Paper-25.htm | 131 B | HTML | View/Open |
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