Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/13156
Title: Phytochemical analysis and reappraisal of diuretic activity of Delphinium brunonianum Royle and its mode of action in experimental rats
Authors: Asif, Hira
Alamgeer, Alamgeer
Ishfaq Ahmad, Muhammad
Hadal Alotaib, Nasser
Saad Alharbi, Khalid
Syed Nasir Abbas Bukhari
Saleem, Hammad
Locatelli, Marcello
Keywords: Delphinium brunonianum
diuretic activity
prostaglandins
muscarinic pathway
HPLC/UV-VIS analysis
Issue Date: 10-Jul-2020
Publisher: Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.
Citation: Asif, H., Ahmad, M. I., Alotaibi, N. H., Alharbi, K. S., Bukhari, S. N. A., Saleem, H., & Locatelli, M. (2020). Phytochemical analysis and reappraisal of diuretic activity of Delphinium brunonianum Royle and its mode of action in experimental rats. Pakistan Journal of Pharmaceutical Sciences, 33(4 (Supplementary)), 1833-1838.
Abstract: The aim of this study was the evaluation of diuretic potential of Delphinium brunonianum. Acute diuretic effect in rats was evaluated 8 h after administration of various doses of crude extract, fractions and hydrochlorthiazide. While, prolonged effect of butanolic fraction was assessed after 7days of oral administration in rats. Thereafter, involvement of different pathways in diuretic activity was also appraised. Furthermore, polyphenolic contents in butanolic fraction were assessed using HPLC/UV-VIS technique. All doses of extract and fractions induced a prominent increase in urine and Na+ excretion with no effect on excretion of K+. Prior administration of indomethacin and atropine considerably avoided the diuretic effect of butanolic fraction. Regarding the quantitative chemical analysis the polyphenolic contents were recorded as 28.78 µg/mg. Thus results of present investigation suggested that Delphinium brunonianum possess remarkable diuretic potential.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/13156
ISSN: 1011-601X
Appears in Collections:Issue 4

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