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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/13192
Title: Calotropis procera (root) escalates functions rehabilitation and attenuates oxidative stress in a mouse model of peripheral nerve injury
Authors: Zafar, Shamaila
Anwar, Haseeb
Qasim, Muhammad
Irfan, Shahzad
Maqbool, Javeria
Sajid, Faiqa
Ali Raza Naqvi, Syed
Hussain, Ghulam
Keywords: Peripheral nerve injury
total oxidant status
total antioxidant capacity
arylesterase and paraoxonase-1
Issue Date: 13-Nov-2020
Publisher: Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi.
Citation: Zafar, S., Anwar, H., Qasim, M., Irfan, S., Maqbool, J., Sajid, F., ... & Hussain, G. (2020). Calotropis procera (root) escalates functions rehabilitation and attenuates oxidative stress in a mouse model of peripheral nerve injury. Pakistan Journal of Pharmaceutical Sciences, 33.
Abstract: Peripheral nerve injuries result in sensorimotor functional loss, leading to permanent disability and physical dependency with immense cost and reduced quality of life. These injuries are among those complicated medical situations which still are waiting for their first-line treatment. This study was designed to investigate the role of Calotropis procera (crude roots) in accelerating functional retrieval following mechanically induced sciatic nerve injury in healthy albino male mice. Following acclimatization, mice were grouped equally as “Control” fed on normal chow and “Root” fed on C. procera root (100mg/kg/day) mixed chow. A mechanical crush was induced in right sciatic nerve of animals. Behavioral analyses (grip strength, SFI, pinprick and hot plate tests) were conducted for assessing sensorimotor function reclamation and blood was collected for oxidative stress assessment. Significantly earlier retrieval of sensorimotor activities (p<0.05), reduced total oxidant status, increased total antioxidant capacity with prominently enhanced arylesterase and paraoxonase activities (p<0.001) in treatment group suggested positive impact of C. procera roots on quickening functional recovery and combating oxidative stress following nerve injury. Thus C. procera root can be considered as potential candidate drug for further investigation to seek bioactive compound/s that may actually responsible for ameliorative functional recovery following nerve injury.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/13192
ISSN: 1011-601X
Appears in Collections:Issue 6

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