Reno-pancreas protective effects of Spirulina platensis in alloxan induced diabetic rats

Abstract

A large variety of herbal elements are employed in the treatment of diabetes for their better efficacy and safety compare to synthetic drugs. In this experiment Spirulina platensis was used to evaluate the antidiabetic, kidney & pancreas injury protective potential in alloxan induced diabetic rats. Male Long Evans rats having six weeks of age were used for the experiment. Diabetes was induced by intraperitoneal injection of alloxan @ 150 mg/kg and experiment was carried out for a period of six weeks. The study was conducted by dividing the animal into three groups (n=7 rats in each group) indicated as with Group-A (healthy control); Group-B (diabetic control); Group-C (Diabetic rats treated with Spirulina platensis @ 400 mg/kg). Spirulina platensis reduced blood glucose significantly (P<0.01) and improved the body weight losses significantly (P<0.05) compared to diabetic rats after six weeks treatment. The histopathological alteration was observed in the kidney of diabetic rats which was characterized by glomerular hypertrophy, tubular necrosis and interstitial fibrosis. Marked improvements in the histopathological change were noticed in the kidneys of diabetic rats treated with Spirulina platensis. Pancreatic injury was produced by alloxan induction in rats characterized by destruction of the pancreatic β cells mostly in the central portion of the islets of langerhans and lymphocytic infiltrations, atrophy, and interstitial fibrosis, which were suppressed by Spirulina platensis. In addition, alloxan induced diabetic rats showed increased plasma lipid peroxidase level which was ameliorated by Spirulina platensis treatment. Along with previous report the anticipated results would concluded that Spirulina platensis having antioxidant compounds could protect renal tissues damage, stimulate regeneration and reactivation of pancreatic β- cells in alloxan induced diabetic rats.