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Title: | Vicissitudes in polyphenolic extract-based high internal phase creams (HIPCs)- effect of storage temperature dependent characteristics |
Authors: | Ali, Atif Akhtar, Naveed Khan, Hira Adnan Jamil, Qazi Hussain Shah, Sajid Naeem, Muhammad Hassham Hassan Bin Asad, Muhammad |
Keywords: | Formulation rheology storage temperature high internal phase creams |
Issue Date: | 7-Nov-2020 |
Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, university of Karachi. |
Citation: | Ali, A., Akhtar, N., Khan, H., Jamil, Q. A., Shah, S. H., Naeem, M., & Asad, M. H. H. B. (2020). Vicissitudes in polyphenolic extract-based high internal phase creams (HIPCs)-effect of storage temperature dependent characteristics. Pakistan Journal of Pharmaceutical Sciences, 33(6), 2521-2527. |
Abstract: | The purpose of this investigation was to evaluate the vicissitudes in polyphenolic extract- based high internal phase creams (HIPCs) and effect of storage temperature dependent characteristics. Rheological parameters, that is, power law and IPC analysis with its physical characteristics were exploredat different storage temperatures (8°, 25°, 40° and 40° with 75% relative humidity- RH) with different time intervals up to 2 months of newly formulated poly-phenolic extract- based high internal phase cream and its comparison with base. Polyphenolic- based HIPCs showed nonNewtonian- pseudo plastic tendencies in vicissitudes with time and storage temperatures. Data analysis with Power Law and IPC paste was found to fit to all the rheograms. Flow index, shear sensitivity factor, consistency Index and 10 RPM of freshly prepared HIPCs with and without encapsulated polyphenolic extract were found to be 0.5,0.53, 386.4 cP, and 432.9 cP, respectively.The viscosities were fallen with rise in shear stress.There was no change in color, electrical conductivity, liquefaction and phase separation after centrifugation in any sample of polyphenolic extract– based HIPCs and its base. Polyphenolic- based extract HIPCs behaved non-Newtonian- pseudo plastic tendencies and showed stability up to 2 months and can be directed absolutely to shield skin against ultraviolet radiation (UV) intervened oxidative mutilation. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/13224 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 6 |
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File | Description | Size | Format | |
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Paper-7.htm | 130 B | HTML | View/Open |
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