Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/13235
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dc.contributor.authorLiu, Bao-
dc.contributor.authorHuang, Xiangming-
dc.contributor.authorXia, Lina-
dc.contributor.authorWang, Dandan-
dc.contributor.authorMu, Dehong-
dc.contributor.authorTian, Li-
dc.date.accessioned2022-10-18T10:47:35Z-
dc.date.available2022-10-18T10:47:35Z-
dc.date.issued2021-07-20-
dc.identifier.issn1011-601X-
dc.identifier.urihttp://142.54.178.187:9060/xmlui/handle/123456789/13235-
dc.description.abstractAllergic rhinitis (AR) is one of the most common atopic disorders, which seriously affects patients' quality of life. Yupingfeng (YPF) Power is a traditional Chinese herb formula, and its oral dosage form has been widely used for the treatment of AR in Asian countries. In this study, we investigated the effects of YPF nasal drops on ovalbumin (OVA) sensitized/stimulated allergic rhinitis in rats. A Sprague-Dawley (SD) rat model of OVA-induced AR was established and then treated with three doses of YPF nasal drops. Besides, histopathological features, eosinophil cationic protein (ECP) in the nasal mucosa, and expression of type 1 helper T (Th1)/type 2 helper T (Th2)-related cytokines in serum were analyzed. The results showed that YPF nasal drops alleviated the injury of nasal mucosal epithelial structure, promoted the recovery of ciliary morphology and function and reduced interstitial edema and inflammatory cell infiltration to some extent. Moreover, YPF nasal drops regulated imbalance in Th1/Th2 cells caused by AR via regulating downward the expression of interleukin 4 (IL-4) and adjusting upward the expression of interferon-γ (INF-γ) and interleukin 12 (IL-12). Furthermore, it inhibited the expression of ECP in nasal epithelial eosinophil-specific granules. The findings of this study provided a new perspective for the treatment of AR with YPF nasal drops based on Traditional Chinese Medicineen_US
dc.language.isoenen_US
dc.publisherKarachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachien_US
dc.subjectAllergic rhinitisen_US
dc.subjectYupingfeng nasal dropsen_US
dc.subjecthistopathology of nasal mucosaen_US
dc.subjecteosinophil cationic proteinen_US
dc.subjectserum cytokinesen_US
dc.subjectratsen_US
dc.titleEffects of Yupingfeng nasal drops on serum cytokines, histopathology and eosinophil cationic protein in nasal mucosa of rats with allergic rhinitisen_US
dc.typeArticleen_US
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