To find out the Interrelationship of Factor X1 and D-dimer as a Marker of Increased Risk of Deep Venous Thrombosis in Dengue Haemorrhagic Fever

Abstract

Background: Infectious diseases pose a serious hazard to human health security especially in the developing countries because of inadequate resources to fight them. These pathogens are distinguished by a special mode of pathogenesis and, some time has a vast host range. Aim: To find the interrelationship of factor X1 and D-dimer as a marker of increased risk of deep venous thrombosis in dengue haemorrhagic fever. Methods: The study included 81 confirmed patients of dengue hemorrhagic fever with age greater than 18 years. The data was collected by the proforma prepared for the study for variables including age, D dimmer coagulation factor XI. The patients with dengue hemorrhagic fever were divided in four grades according to WHO criteria. Results: Majority of dengue patients were of age less than 30 years. Other patients have an age range of 30-45 yrs and 45–60 yrs. There were 53(65.4%) cases belong to DHF-I, 20(24.6%) cases belong to DHF-II, and 8(9.88%) cases belong to DHF-III, and DHF-IV. 55(67.9%) were male and 26(32.1%) were female. The factor XI activity increased in 12 cases of DHF grade II, 8 cases of grade III & IV, while it was normal in DHF I patients. The D dimmer levels were also significantly raised among group DHF-I patients had levels <700 in DHF-II were 40%, with a range of 200- 700 and 60% with a range of 700- 1200. In DHF-III 62.5% had a range of 700-1200 and 37.5% had > 1200.