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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/13280
Title: Potential protective role of curcumin powder to regulate arsenicinduced hepatorenal toxicity and hyperlipidemic metabolic dysfunction in rat model
Authors: Haleem, Muhammad Ammar
Khan, Safwan Ahmad
Khan, Muhammad Kamran
Ahmad, Rabia Shabir
Naqvi, Syed Ali Raza
Imran, Muhammad
Ahmed, Muhammad Haseeb
Anwar, Haseeb
Mahr Un Nisa
Keywords: Curcumin
arsenic
efficacy
liver
kidney
rat model
Issue Date: 20-Jul-2021
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi
Abstract: The present work was conceptualized to determine the potential protective effects of curcumin on arsenicinduced kidney damage in male albino rat model. Thirty six male albino rats were selected, weighed about 175±10g and classified into four groups (9 rats in each group) such as C group (control with basal diet), Cur group (curcumin 200mg/kg body weight), AI group (arsenic-induced 5mg/kg body weight) and AI + Cur group (arsenic 5mg/kg+curcumin 200mg/kg body weight), respectively. Arsenic and curcumin were offered through the gavage method once daily with basal diet. The different analyzed parameters showed that arsenic-induced elevation of aspartate amino transferase, alkaline phosphatase, bilirubin urea, alanine aminotransferase and creatinine significantly decreased with curcumin application in AI + Cur group. Similarly, the statistically significant decline of low-density lipoprotein (LDL), cholesterol, triglyceride and increased in high-density lipoprotein (HDL) was observed in rats of AI + Cur group with curcumin treatment as compared to the rats of AI group. The level of different enzymes of the liver as well as kidney was noted depleted on arsenic exposure whereas increased in level was observed with curcumin application in AI + Cur group. Moreover, pathological histology changes were also recorded. The outcomes suggest that curcumin has a potential effect against arsenic-induced toxicity in biological model.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/13280
ISSN: 1011-601X
Appears in Collections:Issue No.4 (Supplementary)

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