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Please use this identifier to cite or link to this item: http://142.54.178.187:9060/xmlui/handle/123456789/13339
Title: Synthesis, characterization, antibacterial, hemolytic and thrombolytic activity evaluation of 5-(3-chlorophenyl)-2-((N-(substituted)-2- acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives
Authors: Rehman, Aziz-ur-
Khan, Samreen Gul
Bokhari, Tanveer Hussain
Anjum, Fozia
Akhter, Naheed
Rasool, Shahid
Ali Shah, Syed Adnan
Shahid, Muhammad
Arshad, Aneesa
Keywords: 1,3,4-Oxadiazole
acetamides
antibacterial activity
thrombolytic activity
hemolytic activity
Issue Date: 15-Mar-2020
Publisher: Karachi:Pakistan Journal of Pharmaceutical Sciences, University of Karachi.
Citation: Khan, S. G., Bokhari, T. H., Anjum, F., Akhter, N., Rasool, S., Shah, S. A. A., ... & Arshad, A. (2020). Synthesis, characterization, antibacterial, hemolytic and thrombolytic activity evaluation of 5-(3-chlorophenyl)-2-((N-(substituted)-2-acetamoyl) sulfanyl)-1, 3, 4-oxadiazole derivatives. Pakistan journal of pharmaceutical sciences.
Abstract: A novel series of 5-(3-Chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives was efficiently synthesized and screened for antibacterial, hemolytic and thrombolytic activities. The molecule 7c remained the best inhibitor of all selected bacterial strains and furthermore possessed very low toxicity, 8.52±0.31. Compound 7a 7b and 7f showed very good thrombolytic activity relative to Streptokinase employed as reference drug. In addition to low toxicity and moderately good thrombolytic activity, the synthesized compounds possessed excellent to moderate antibacterial activity, relative to ciprofloxacin. All compounds especially 7b and 7f can be consider for further clinical studies and might be helpful in synthesis of new drugs for treatment of cardiovascular diseases.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/13339
ISSN: 1011-601X
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