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Title: | Synthesis, characterization, antibacterial, hemolytic and thrombolytic activity evaluation of 5-(3-chlorophenyl)-2-((N-(substituted)-2- acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives |
Authors: | Rehman, Aziz-ur- Khan, Samreen Gul Bokhari, Tanveer Hussain Anjum, Fozia Akhter, Naheed Rasool, Shahid Ali Shah, Syed Adnan Shahid, Muhammad Arshad, Aneesa |
Keywords: | 1,3,4-Oxadiazole acetamides antibacterial activity thrombolytic activity hemolytic activity |
Issue Date: | 15-Mar-2020 |
Publisher: | Karachi:Pakistan Journal of Pharmaceutical Sciences, University of Karachi. |
Citation: | Khan, S. G., Bokhari, T. H., Anjum, F., Akhter, N., Rasool, S., Shah, S. A. A., ... & Arshad, A. (2020). Synthesis, characterization, antibacterial, hemolytic and thrombolytic activity evaluation of 5-(3-chlorophenyl)-2-((N-(substituted)-2-acetamoyl) sulfanyl)-1, 3, 4-oxadiazole derivatives. Pakistan journal of pharmaceutical sciences. |
Abstract: | A novel series of 5-(3-Chlorophenyl)-2-((N-(substituted)-2-acetamoyl)sulfanyl)-1,3,4-oxadiazole derivatives was efficiently synthesized and screened for antibacterial, hemolytic and thrombolytic activities. The molecule 7c remained the best inhibitor of all selected bacterial strains and furthermore possessed very low toxicity, 8.52±0.31. Compound 7a 7b and 7f showed very good thrombolytic activity relative to Streptokinase employed as reference drug. In addition to low toxicity and moderately good thrombolytic activity, the synthesized compounds possessed excellent to moderate antibacterial activity, relative to ciprofloxacin. All compounds especially 7b and 7f can be consider for further clinical studies and might be helpful in synthesis of new drugs for treatment of cardiovascular diseases. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/13339 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 1 |
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