Important Mortality Predictors in Patients of Decompensated Chronic Liver Disease Presenting to a Tertiary Care Hospital of Lahore

Abstract

Background: Decompensated chronic liver disease (DCLD) is one of the leading cause of mortality worldwide. There are various factors which predict mortality of patients in cirrhosis. We investigated different factors which affect patient prognosis in DCLD. Aim: To assess important mortality predictor in patients of DCLD presenting to a tertiary care hospital of Lahore. Study design: A cross sectional study. Place of study: Medicine department, Services Hospital Lahore. Methods: Sixty two patients with decompensated cirrhosis admitted in medicine department were included in our study. After detailed history and examination, laboratory investigations were sent and the patients were followed for a period of 30 days. Clinical bio-data and laboratory investigations of survivors and non-survivors were compared. Results: According to the results of our study, mean age of patients was 54.06±7 years. It is evident from the study that prothrombin level and creatinine were associated with increased mortality of patients (p=0.0029 and 0.0001 respectively). Furthermore ascites, hepatic encephalopathy and CTP were also significantly correlated with mortality outcome of patients with DCLS (p=0.001,0.0001,0.001 respectively). It was also seen that total bilirubin and albumin did not show any significant correlation with mortality in patients of DCLS (p=0.6339 and 0.1462). Conclusion: Serum prothrombin, creatinine, CTP, ascites and hepatic encephalopathy are important mortality predictors in DCLD patients.