Urine Protein to Creatinine Ratio: An Early Predictor of Chronic Kidney Disease in A Group of Pre-Eclamptic Women

Abstract

Background: Preeclampsia is the most grave form of pregnancy complications due to hypertension. Although hypertension is usually observe in pregnancy, renal participation secondary to this circumstance has not been considerably explored. Aim: To find out the role of urinary protein to creatinine ratio as an early predictor of chronic kidney disease. Methods: Fifty pregnant women who met the criteria of preeclampsia were included in the study. The Blood pressure was noted by sphygmomanometer. Urinary protein was estimated by Lowery method. Serum creatinine was estimated by Jaffe reaction. Protein-to-creatinine ratio is calculated. Results: Mean age of 31 cases was 26 and of 18 cases was 32 years. Blood pressure was 140/93 in 31 cases and 142/96 mmHg in 18 cases with gestational age was 25 weeks in both cases. All patients belong to poor and middle class. Obstetric complication including abortion and cesarean section were more common in 31 cases or young age compared to 18 cases or middle age group. It is observed that moderately increased urinary protein creatinine ratio was observed in 31 cases with value of 408.89 and in 18 cases, severely increased ratio was observed with a value of 453.58. Conclusion: It is concluded that urinary protein to creatinine ratio may be use to detect kidney disease and damage early especially in preelamptic patients. The test may be use to minimize the damage and prolong kidney function.