Hypersplenism in Chronic Liver Disease

Abstract

Background: Chronic liver disease (CLD) is a serious and irreversible disease. It is end result of hepatocellular injury and lead to various complications like hypersplenism. Aim: To determine the frequency of Hypersplenism in CLD. Methods: This was a Cross sectional study that was conducted at Department of Medicine, Services Hospital, Lahore April 2016 to November 2016 in which 100 cases of CLD with age range of 30-60 years were selected.These cases were then assessed for serum albumin, bilirubin, INR, abdominal examination for ascites and clinical assessment to look for hepatic encephalopathy to label the child pugh classification in cases with chronic liver disease. These cases then underwent bone marrow examination and those with normal to hyper cellular marrow were labeled as Hypersplenism. Results: Out of total 100 patients in present study, there were 64 males and 36 females with mean age of 51.17±5.45 years. Hypersplenism was seen in 60 cases (60%). Hypersplenism was seen in 44 males (68.75%) and 16 females (44.44%) out of their respective groups with p=0.72. Hypersplenism was higher in child pugh class C as compared to B where it was seen in 29(72.5%) out of 40 cases as compared to 31(51.67%) out of 60 cases with p= 0.14. Conclusion: Hypersplenism is common in chronic liver disease and is more common in male gender and those with child pugh class C.