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Title: | Effects of shikonin from Zicao on high-fat diet-induced nonalcoholic fatty liver disease in rats |
Authors: | Yang, Weijia Yang, Minchun Yao, Hui Ma, Yelin Ren, Xuanxuan Teng, Long Wang, Tao |
Keywords: | Nonalcoholic fatty liver disease lipid accumulation liver injury fibrosis shikonin |
Issue Date: | 16-Jan-2021 |
Publisher: | Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi |
Abstract: | In this study, we aim to investigate whether shikonin prevents against NAFLD. After feeding high-fat diet (HFD) for 10 weeks, Sprague-Dawley rats were received different doses of shikonin (5mg/kg/day, 10mg/kg/day and 20mg/kg/day) by gavage for the last 12 weeks of a total of 22 weeks of a HFD. Our results showed that total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol, aspartate aminotransferase and alanine aminotransferase were significantly increased, while high-density lipoprotein cholesterol was decrease, accompanied by hepatic injury and lipid accumulation in HFD-fed rats. Shikonin treatment attenuated the above biochemical and histopathological changes. Similarly, HFD-induced the increase of hepatic TC and TG levels were also ameliorated by shikonin treatment. Furthermore, shikonin observably mitigated HFD-induced the liver fibrosis and the increase of plasminogen activator inhibitor type 1, connective tissue growth factor, collagen III and IV expression. Additionally, shikonin markedly inhibited HFD-induced the decrease of proliferator-activated receptor γ (PPARγ) and matrix metalloproteinases-9 (MMP-9) expression and the increase of tissue inhibitor of metalloproteinases-1 (TIMP-1) expression in liver tissue. This study demonstrates that shikonin ameliorates hepatic lipid dysregulation and fibrosis through PPARγ and MMP-9/TIMP1 axis, suggesting that shikonin may be a potential therapeutic agent for the treatment of NAFLD. |
URI: | http://142.54.178.187:9060/xmlui/handle/123456789/13434 |
ISSN: | 1011-601X |
Appears in Collections: | Issue 01 |
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