Salicylic acid attenuates gentamicin-induced nephrotoxicity in rabbits

Abstract

Gentamicin (GM) is a generally utilized as an antibiotic against dangerous and life threatening contaminations, yet its value is restricted by the development of nephrotoxicity. The present investigation was intended to decide the defensive impact of salicylic acid (SA) in gentamicin-induced nephrotoxicity in rabbits. Quantitative assessment of gentamicin-induced structural changes and level of functional modifications in the kidneys were performed by biochemical examinations keeping in mind the end goal is to decide the potential protective impacts of SA co-administration with gentamicin. Gentamicin was seen to cause a serious nephrotoxicity which was proved by a plasma urea, plasmacreatinine, plasma uric acid, plasma Na+ , plasma K+ , intra-erythrocyte Na+ and intra-erythrocyte K+ levels. On the other hand, simultaneous SA administration protected kidney tissue against the oxidative damage and the nephrotoxic effect caused by GM treatment. The outcomes from our investigation show that SA supplement lessens oxidative-stress related to renal damage by reducing oxygen free radicals in gentamicin-treated rabbits.