CORRECTIVE MEASURES OF THE PAKISTAN GOVERNMENT AGAINST AN INVINCIBLE XDR TYPHOID FEVER INFILTRATING THE SOUTHERN PAKISTAN

Abstract

Salmonella.typhi a typhoid causing organism, has developed resistance to oral first line (Ampicillin and Flouroquinolones) and oral third line antibiotics (Chloramphenicol) due to enzymatic and genetic changes. As a result XDR Fever as an epidemic has taken the world by storm with its vivid target of engulfing the mortals and resist towards countless medical therapies. Here, a set of medical regime with precautions are being posed to let the steam out and control the disease. Diverse variety of journal with articles over the subject disease has been scrutinized to get a clear picture of the epidemic from year 2007 till 2020. Following credible databases have been probed: Pub med, ASM Journal, NEJM organization, Oxford Academy, Cidrap, ReAct, Sciencemeg, New England Journal of Medicine. On the basis of literature evaluation, up till now 17756 cases have been observed in Southern part of Pakistan regarding XDR typhoid among which 2000 cases are reported to be fatal. The frequently prescribed treatment against XDR are Azithromycin and/or Carbapanem, while many other drugs with increased immunity and better treatment are available which are unaffordable for Pakistan. To avoid antibiotic resistance, Pakistan should start Antimicrobial resistance program (AMR program) as well as Anti-microbial stewardship program (ASP).