Please use this identifier to cite or link to this item: http://localhost:80/xmlui/handle/123456789/13473
Title: Effects of dexmedetomidine combined with citrate sufentanil on the prognosis of patients with severe pneumonia and respiratory failure requiring mechanical ventilation
Authors: Wang, Jiao
Huang, Jing
Ji, Mingxia
Keywords: Dexmedetomidine
combination
sufentanil
severe pneumonia
respiratory failure
mechanical ventilation
prognosis
Issue Date: 16-Jan-2021
Publisher: Karachi: Faculty of Pharmacy & Pharmaceutical Sciecnes, University of Karachi
Abstract: To investigate the effects of dexmedetomidine combined with citrate sufentanil on the prognosis of patients with severe pneumonia and respiratory failure requiring mechanical ventilation. 70 patients with severe pneumonia complicated with respiratory failure who were treated with mechanical ventilation were selected and divided into the combined group and the control group. The control group underwent mechanical ventilation treatment and used dexmedetomidine for sedation and analgesia, while the combined group had sufentanil analgesia in addition to the treatment of the control group. Ramsay sedation score, visual analogue scale (VAS) and pulmonary function indicators were compared between the two groups before treatment, 24h after treatment, and after extubation. After 24h treatment and extubation, the blood oxygen saturation (SpO2), oxygenation index (OI) and arterial oxygen partial pressure (PaO2) in the combined group were higher than those in the control group; at the same time, the serum interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and malondialdehyde (MDA) levels were lower (P<0.05). Mortality during hospitalization of the combined group was lower than the control group (P<0.05). Dexmedetomidine combined with sufentanil citrate can effectively improve sedative and analgesic effects, stress response, pulmonary function and prognosis in patients with severe respiratory failure requiring mechanical ventilation.
URI: http://142.54.178.187:9060/xmlui/handle/123456789/13473
ISSN: 1011-601X
Appears in Collections:Issue 01 (Special)

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