ANTICANCER POTENTIAL OF FICUS LYRATA L. AGAINST INDUCED HEPATOCELLULAR CARCINOMA

Abstract

Hepatocellular Carcinoma is the 6th most predominantly existing cancer and the second largest contributor to human mortality the world over. The present study provides therapeutic as well as prophylactic method for the treating induced Hepatocelluar carcinoma (HCC) by administrating a plant ethanolic extract and compared with standard drug Sorafenib (in medical use for the treatment of Hepatocellular Carcinoma). Hepatocellular carcinoma (HCC) was induced in Oryctolagus cuniculus (Rabbits) by the administration of Carbon tetrachloride. The induced animals were treated with plant extract afterwards. Curative and protective effects of plant extract were effectively analysed by monitoring physiological changes (pH of saliva, temperature, blood glucose, body weight) in induced Hepatic Carcinomic O. cuniculus. Furthermore, Hematological investigations (Hb, RBC, TLC, MCV, MCH, MCHC and Platelets), changes in Liver Biochemical Enzymes (Alkaline phosphatase, Aspartate amino Transferase and Alanine aminotransferase) and Hepatic Carcinoma Marker (Alpha Fetoprotein) efficiently marked Therapeutic as well as Prophylactic outcomes followed by Histo-Pathological studies of Carcinomic and healthy livers following Hematoxylin and Eosin Staining.