An experimental study on the treatment of diabetes-induced cognitive disorder mice model with exosomes deriving from mesenchymal stem cells (MSCs)

Abstract

The occurrence rate of senile dementia among diabetes patients is high, but there is still no effective therapeutic method. This study aimed to explore curative effect of exosomes deriving from MSCs treating diabetesinduced cognition impairment. After BM-MSCs culture was purified, Western Blot and electron microscope were used to identify exosomes which were injected into diabetes mouse through intracranial injection. Purified exosomes in Western blot analysis and electron microscope observation were verified. After therapy with exosomes deriving BMMSC, mouse cognition impairment and histologic abnormity were recovered. Exosomes deriving from BM-MSCs can be a new preparation treating cognition with application prospect.