Design and formulation of nano-porous controlled porosity osmotic pumps (CPOPs) containing a poorly water soluble drug, glibenclamide

Abstract

The aim of this study was to design and develop controlled porosity osmotic pumps containing glibenclamide (as an insoluble agent) coated with nano-scale pore formers. Solubility enhancement methods including co-grinding with an anionic surfactant and pH adjustment in core formulation were employed and the prepared cores were coated with nano-suspension coating method. The prepared nano-porous osmotic pump (CPOP) system assessed by comparative parameters including D24h (cumulative release percentage after 24h), tL (lag time of the drug release from device), drug release rate from device and RSQzero. Solubility studies of glibenclamide co-ground with an anionic surfactant showed that by increasing the concentration of SLS to 83.33% (ratio of drug: SLS 1:5) in the presence of calcium carbonate, the solubility of glibenclamide was enhanced remarkably. Release study also displayed enhanced D24h and improved kinetic related parameter (RSQ zero) by increasing SLS and calcium carbonate in the core formulation via nano-porous CPOPs. It can be concluded that by employing both co-grinding technology and pH adjustment method in core formulation of glibenclamidenano-suspension coated CPOPs, enhanced D24h, drug release rate and improved kinetic related parameter (RSQ zero) was achieved.