Role of Hyperurecemia in Progress of Diabetic Nephropathy

Abstract

Background: Diabetes mellitus is very common in our community. Long standing and uncontrolled diabetes leads to various micro and macrovascular complications. Diabetic nephropathy is one of the common and deadly complication. It has been observed that in these patients along with elevated serum urea and creatinine, serum uric acid level was high. Aim: To see the association of hyperuricemia and diabetic nephropathy. Study design: It was a cross sectional observational study conducted at GTHS. Method: Total 300 patients were enrolled in the study including both males and females of ages greater than or equal to 40 years.Only type 2 diabetic patients were included in our study.Patients of type 1 diabetes or drug induced diabetes (iatrogenic) or gestational diabetic or pre-diabetic patients were excluded. 150 patients with diabetes mellitus without any evidence of nephropathy (micro or macroalbuminuria) from outpatient department of GTHS were collected. Results: Out of 150 patients in group 1 ,72 (48%)were males and 78(52%)were females. In male patients 55(77.7%) were having serum uric acid within normal range.16 patients (22%) were having impaired serum uric acid i.e.> or equal to 7mg/dl. In female patients (78), 43(55%) were having normal serum uric acid i.e.either≤6mg/dl and 35 females (45%)were having high serum uric acid levels i.e.>or equal to 6 mg/dl.HbA1C level was mostly within desirable range in group 1 that is between 5 to 6 in 74% patients. Duration of diabetes was also less than 4 years in 67% patients. In group 2, 83 were males (55%) and 67 were (45%) females. Conclusion: Diabetic nephropathy shows a positive relationship with increased serum uric acid levels.So, increased serum uric acid levels may be controlled by appropriate drugs and thus progress of diabetic nephropathy may be slowed.