SOLVENT-FREE RAPID MICROWAVE SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2,4-(I H, 3H)PYRIMIDINEDIONE

Abstract

Microwave-assisted method has wide application in combinatorial chemistry. It has become a powerful tool in building the bioactive and pharmaceutical important compounds library within a short time. In view of a pronounced effect of Microwave-assisted methods in synthetic chemistry and their importance in drug discovery, a systematic work on the solvent-free synthesis of 2,4-(IH,3H)Pyrimidinedione(uracil) was carried out. Comparison was made between classic (conventional) and Novel (microwave-assisted) methods and it was found that compounds synthesized by microwave-assisted method showed better yield and reduced reaction time under safe and environment-friendly conditions, while conventional methods were tedious and time consuming. The structure elucidation of synthesized compounds was done by its melting/boiling points, solubility, thin layer chromatography (TLC) techniques and spectral analysis i.e ultraviolet (UV), Fourier transform infrared spectroscopy (FTIR) and Gas chromatography–mass spectrometry (GC-MS) were used to get the results. The pharmacological evaluation of synthesized compound was investigated by its antiviral activities against Lasota strain of NDV (ranikhait disease virus) and it showed the positive activity.